SAB4503898
Anti-phospho-Aurora Kinase (pThr288) antibody produced in rabbit
affinity isolated antibody
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 45 kDa
species reactivity
human, rat, mouse
concentration
~1 mg/mL
technique(s)
ELISA: 1:1000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
phosphorylation (pThr288)
Gene Information
human ... AURKA(6790)
General description
Aurora kinase A (AURKA) belongs to the serine/threonine kinase family. It is localized to centrosomes. AURKA gene is located on human chromosome 20q13.2.
Immunogen
The antiserum was produced against synthesized peptide derived from human Aurora Kinase around the phosphorylation site of Thr288.
Immunogen Range: 256-305
Immunogen Range: 256-305
Application
Anti-phospho-Aurora Kinase (pThr288) antibody produced in rabbit has been used in immunofluorescence staining.
Biochem/physiol Actions
Aurora kinase A (AURKA) is involved in maintaining the stability of mitosis and chromosomes. During mitosis, AURKA participates in centrosome maturation control, mitotic entry, bipolar spindle formation, and segregation. AURKA also participates in chromosome alignment and cytokinesis. It controls several oncogenic signaling pathways. AURKA plays a major role in the self-renewal, reprogramming, and differentiation of stem cells. Knockdown of AURKA gene affects the maturation of the centrosome. Abnormality in the AURKA gene leads to aberrant cell division and aneuploidy, which in turn affects the stability of the genome and contributes to carcinogenesis. Overexpression of the AURKA gene is seen in gastrointestinal, pancreatic, and liver cancers. It can act as a candidate gene to predict colorectal adenocarcinoma.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Ahmed Katsha et al.
Molecular cancer, 14, 106-106 (2015-05-20)
Gastrointestinal (GI) cancers are a major cause of cancer-related deaths. During the last two decades, several studies have shown amplification and overexpression of Aurora kinase A (AURKA) in several GI malignancies. These studies demonstrated that AURKA not only plays a
Richard A Dicioccio et al.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 13(10), 1589-1594 (2004-10-07)
STK15 is a putative oncogene that codes for a centrosome-associated, serine/threonine kinase, the normal function of which is to ensure accurate segregation of chromosomes during mitosis. Amplification of STK15 has been reported in ovarian tumors, suggesting a role in ovarian
Yan-Ru Li et al.
Aging, 11(4), 1110-1128 (2019-02-21)
Tight control of energy metabolism is essential for normal cell function and organism survival. PKM (pyruvate kinase, muscle) isoforms 1 and 2 originate from alternative splicing of PKM pre-mRNA. They are key enzymes in oxidative phosphorylation and aerobic glycolysis, respectively
Hyun Min Koh et al.
Journal of pathology and translational medicine, 51(1), 32-39 (2016-12-26)
Aurora kinase A (AURKA), or STK15/BTAK, is a member of the serine/threonine kinase family and plays important roles in mitosis and chromosome stability. This study investigated the clinical significance of AURKA expression in colorectal cancer patients in Korea. AURKA protein
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