Anti-Factor VIII Antibody detects endogenous levels of total Factor VIII protein.
Blood clotting factor VIII (FVIII), a nonenzymatic cofactor of activated factor IX (FIXa) is of ~330 kDa. It has three homologous A-domains, a unique B-domain and two C-domains. It is located on chromosome Xq28.
Immunogen
The antiserum was produced against synthesized peptide derived from human Factor VIII.
Immunogen Range: 2161-2210
Biochem/physiol Actions
Mutation in the factor VIII gene (F8) results in haemophilia A (HA). Higher levels of VIII:C (FVIII:C) leads to venous and arterial thromboembolism. The factor VIII serve as a procoagulant cofactor in the intrinsic blood coagulation pathway.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Mutational spectrum and deep intronic variants in the factor VIII gene of haemophilia A patients. Identification by next generation sequencing
Bach JE, et al.
Hamostaseologie, 36(S 02), S25-S28 (2016)
Localization of human factor FVIII inhibitor epitopes to two polypeptide fragments
Fulcher CA, et al.
Proceedings of the National Academy of Sciences of the USA, 82(22), 7728-7732 (1985)
Mapping of X-linked myxomatous valvular dystrophy to chromosome Xq28
Kyndt F, et al.
American Journal of Human Genetics, 62(3), 627-632 (1998)
An in silico and in vitro approach to elucidate the impact of residues flanking the cleavage scissile bonds of FVIII
Pezeshkpoor B, et al.
PLoS ONE, 12(7) (2017)
Elevated levels of FVIII:C within families are associated with an increased risk for venous and arterial thrombosis
Bank I, et al.
Journal of Thrombosis and Haemostasis, 3(1), 79-84 (2005)
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