S9549
Superoxide dismutase–polyethylene glycol from bovine erythrocytes
lyophilized powder, ≥1,350 units/mg protein
Synonym(s):
PEG-SOD
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About This Item
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form
lyophilized powder
Quality Level
200
400
specific activity
≥1,350 units/mg protein
mol wt
5000 Da
composition
Protein, ≥20% biuret
extent of labeling
≥10 mol PEG per mol protein
storage temp.
−20°C
General description
Superoxide dismutase from bovine erythrocytes is a copper and zinc superoxide dismutase. Copper and zinc ions are coordinated by active site histidine residues. It has β-barrel structure.[1]
Application
Superoxide dismutase-polyethylene glycol from bovine erythrocytes has been used:
- in the incubation of lung slices for measurement of dihydroethidium (DHE) fluorescence in cultured bovine pulmonary artery endothelial cells[2]
- as supplement in T cell culture to investigate its effect on cytokine production[3]
- in the preincubation of the carotid artery sections prior to DHE treatment[4]
Biochem/physiol Actions
Superoxide dismutase-polyethylene glycol (SOD-PEG) is effective than SOD in scavenging free radicals in injuries. It reduces oxidative damage in ovarian follicles cell culture and during ovarian tissue transplantation.[5] SOD-PEG is also effective in scavenging superoxide in mitochondrial abnormalities.[6]
Packaging
Package size based on protein content
Other Notes
Superoxide dismutase from bovine erythrocytes coupled to methoxy-polyethylene glycol, M.W. 5,000, through secondary amine linkage.
Physical form
Lyophilized powder containing PEG plus 5% citrate buffer salts
Preparation Note
Enzyme derived
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Resp. Sens. 1
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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