Chemical research in toxicology, 22(12), 1938-1947 (2009-12-08)
Cytochrome P450 1a1 (Cyp1a1) is a phase I xenobiotic-metabolizing enzyme, the expression of which is mainly driven by the aryl hydrocarbon receptor (AhR). Cyp1a1 messenger (m)RNA is labile. Our study indicates that 1-nitropyrene (1-NP) highly induced Cyp1a1 protein expression, although
The formation of hydroxynitropyrene (OHNP) via a photochemical reaction of 1-nitropyrene (1-NP) was demonstrated using a UV irradiation system. The photoreaction of 1-NP in methanol gave products that were hydroxy-substituted at position 1 and mononitro-substituted at positions 2, 3, 5
Airborne particulates were collected at a background site (Wajima Air Monitoring Station; WAMS) on the Noto Peninsula, Japan from January 2006 to December 2007. 1-, 2-nitropyrenes (1-, 2-NPs) and 2-nitrofluoranthene (2-NFR), in the particulates were determined with a sensitive HPLC
The journal of physical chemistry. A, 112(41), 10294-10304 (2008-09-20)
1-Nitropyrene (1NPy) is the most abundant nitropolycyclic aromatic contaminant encountered in diesel exhausts. Understanding its photochemistry is important because of its carcinogenic and mutagenic properties, and potential phototransformations into biologically active products. We have studied the photophysics and photochemistry of
It is reported that diesel exhaust particles contain more 1-nitropyrene (1-NP) than benzo[a]pyrene (B[a]P), both of which are potent carcinogenic compounds. In this study, we show that 1-NP is more potent in reducing cell viability than B[a]P, pyrene, nitrobenzene, and
Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete.
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