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M1778

Sigma-Aldrich

Mucin from porcine stomach

Type III, bound sialic acid 0.5-1.5 %, partially purified powder

Synonym(s):

MUC

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About This Item

CAS Number:
84082-64-4
EC Number:
282-010-7
MDL number:
MFCD00131629
UNSPSC Code:
12352202
NACRES:
NA.61

biological source

Porcine stomach

type

Type III

form

partially purified powder

composition

bound sialic acid, 0.5-1.5%

technique(s)

microbiological culture: suitable

solubility

NaOH: soluble 20 mg/mL

storage temp.

2-8°C

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General description

Mucins or mucus glycoproteins are the main macromolecular components of mammalian mucus. It was also used in a study to evaluate the sputum smears concentrated by cyto-centrifugation for detection of acid-fast bacilli.

Application

Mucin from porcine stomach was used in studies on the binding site of the galactose-specific agglutinin PA-IL from Pseudomonas aeruginosa.

Biochem/physiol Actions

Mucus forms the protective cover for all epithelial surfaces. The major structural component of mucus is gel-forming mucins. The mucus layer covering the intestinal epithelium has the MUC2 mucin as its central molecule. MUC2 is produced by goblet cells.

Preparation Note

Prepared according to the method of Glenister, et al., for use in complex growth media for dental plaque bacteria.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Leyuan Li et al.
Microbiome, 8(1), 33-33 (2020-03-13)
Human-targeted drugs may exert off-target effects or can be repurposed to modulate the gut microbiota. However, our understanding of such effects is limited due to a lack of rapid and scalable assay to comprehensively assess microbiome responses to drugs. Drugs
Lihui Feng et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(5), 2622-2633 (2020-01-24)
Human gut microbiota development has been associated with healthy growth but understanding the determinants of community assembly and composition is a formidable challenge. We cultured bacteria from serially collected fecal samples from a healthy infant; 34 sequenced strains containing 103,102
Anastasia Matthies et al.
Applied and environmental microbiology, 74(15), 4847-4852 (2008-06-10)
The metabolism of isoflavones by gut bacteria plays a key role in the availability and bioactivation of these compounds in the intestine. Daidzein and genistein are the most common dietary soy isoflavones. While daidzein conversion yielding equol has been known
Kenny C Mok et al.
mBio, 11(6) (2020-12-10)
The beneficial human gut bacterium Akkermansia muciniphila provides metabolites to other members of the gut microbiota by breaking down host mucin, but most of its other metabolic functions have not been investigated. A. muciniphila strain MucT is known to use
Abiodun D Ogunniyi et al.
PloS one, 13(7), e0200195-e0200195 (2018-07-17)
There are very few articles in the literature describing continuous models of bacterial infections that mimic disease pathogenesis in humans and animals without using separate cohorts of animals at each stage of disease. In this work, we developed bioluminescent mouse
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