I0879

Inosine 5′-triphosphate trisodium salt

≥95%

• Synonym(s): ITP
• Empirical Formula (Hill Notation): C₁₀H₁₂Na₃N₄O₁₄P₃
• CAS Number: 35908-31-7
• Molecular Weight: 574.11
• MDL number: MFCD00084678
• UNSPSC Code: 41106305
• PubChem Substance ID: 24895910
• NACRES: NA.51

Properties

• Assay: ≥95%
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: [Na].OC1C(O)C(OC1COP(O)(=O)OP(O)(=O)OP(O)(O)=O)n2cnc3C(=O)N=CNc23
• InChI: 1S/C10H15N4O14P3.Na.H/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17;;/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20);;
• InChI key: RIERCUPIZLBNFQ-UHFFFAOYSA-N
• Gene Information: human ... HRAS(3265)

Description

Application

Inosine 5′-triphosphate (ITP) is used in studies on the impact of deamination of ATP and GTP by various enzymes and chemical processes. ITP may be used as a substrate to study the specificity and kinetics of nucleoside-5′-triphosphatase and ATPase. ITP is also used to study activation of various ATPases and GTPases.

Inosine 5′-triphosphate trisodium salt has been used to investigate its influence on the chromosome aberration rate, the mitotic rate, sister-chromatid exchange (SCE) frequency, the proportion of first (X1), second (X2) and third (X3) division metaphases of human peripheral lymphocytes.

Biochem/physiol Actions

Inosine 5′-triphosphate (ITP) has the ability to support the initiation of effector system. It can prevent guanosine 5′-triphosphate (GTP) hydrolysis, that is catalysed by transducin (TD). ITP can proficiently induce secretion in permeabilized cells than GTP. Instead of GTP, ITP can be used for the initiation and the elongation steps of reovirus transcription. ITP can also replace GTP in the activation of G-protein.

Preparation Note

Prepared from Bacterial ATP

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable