H127

p-Fluorohexahydro-sila-difenidol hydrochloride

powder, ≥98% (HPLC)

• Synonym(s): Cyclohexyl-(4-fluorophenyl)-(3-N-piperidinopropyl)silanol hydrochloride, P-F-HHSiD hydrochloride
• Empirical Formula (Hill Notation): C₂₀H₃₂FNOSi · HCl
• CAS Number: 116679-83-5
• Molecular Weight: 386.02
• MDL number: MFCD00078582
• UNSPSC Code: 12352200
• PubChem Substance ID: 24277841
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: H₂O: slightly soluble 1.5 mg/mL; 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: >14 mg/mL; ethanol: soluble
• SMILES string: Cl[H].O[Si](CCCN1CCCCC1)(C2CCCCC2)c3ccc(F)cc3
• InChI: 1S/C20H32FNOSi.ClH/c21-18-10-12-20(13-11-18)24(23,19-8-3-1-4-9-19)17-7-16-22-14-5-2-6-15-22;/h10-13,19,23H,1-9,14-17H2;1H
• InChI key: JMTYYLMGSBSPPK-UHFFFAOYSA-N
• Gene Information: human ... CHRM3(1131)

Description

Application

p-Fluorohexahydro-sila-difenidol hydrochloride (pFHHSid) has been used:

• as the M3/muscarinic acetylcholine receptor antagonist to study its involvement in carbachol induced Egr-1 biosynthesis using human neuroblastoma cells
• as M3 receptor antagonist to test its involvement on N,N-diethyl-m-toluamide (DEET)-induced angiogenesis in human umbilical venous endothelial cells (HUVEC)
• in a study to examine the role of aclidinium on human fibroblast to myofibroblast

Biochem/physiol Actions

High affinity M₃ muscarinic acetylcholine receptor antagonist.

Features and Benefits

This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves