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G9267

Sigma-Aldrich

Glutathionesulfonic acid

Synonym(s):

Glutathione sulfonate

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About This Item

Empirical Formula (Hill Notation):
C10H17N3O9S
CAS Number:
3773-07-7
Molecular Weight:
355.32
MDL number:
MFCD00057929
UNSPSC Code:
12352200
PubChem Substance ID:
24895366
NACRES:
NA.26
Pricing and availability is not currently available.

Assay

≥98% (TLC)

form

powder

technique(s)

ligand binding assay: suitable

color

white

storage temp.

2-8°C

SMILES string

NC(CCC(=O)NC(CS(O)(=O)=O)C(=O)NCC(O)=O)C(O)=O

InChI

1S/C10H17N3O9S/c11-5(10(18)19)1-2-7(14)13-6(4-23(20,21)22)9(17)12-3-8(15)16/h5-6H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)(H,20,21,22)

InChI key

QGWRMTHFAZVWAM-UHFFFAOYSA-N

Amino Acid Sequence

Glu-Cys-Gly

Biochem/physiol Actions

Glutathionesulfonic acid (GSO3), a metabolite of glutathione, is used to increase the tissue-to-plasma concentration ratio of thiopental sodium. Glutathione sulfonate is also used as a modulator of dopamine release and to study glutathione binding sites on proteins such as glutathione transferase.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
058K5004
121K7071
038H5854
030H7827

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L-Glutathione oxidized ≥98% (HPLC)

Sigma-Aldrich

G4376

L-Glutathione oxidized

L-Glutathione reduced ≥98.0%

Sigma-Aldrich

G4251

L-Glutathione reduced

Réka Janáky et al.
Neurochemical research, 32(8), 1357-1364 (2007-04-03)
Glutathione (gamma-glutamylcysteinylglycine, GSH and oxidized glutathione, GSSG), may function as a neuromodulator at the glutamate receptors and as a neurotransmitter at its own receptors. We studied now the effects of GSH, GSSG, glutathione derivatives and thiol redox agents on the
Yuhsuke Ohkawa et al.
Biological & pharmaceutical bulletin, 25(6), 761-765 (2002-06-26)
The effects of glutathione (GSH) and glutathionesulfonic acid sodium salt [N-(N-gamma-L-glutamyl-L-beta-sulfoalanyl)glycine sodium salt, GSO3Na], which is a minor metabolite of GSH, on the pharmacokinetics of thiopental sodium were investigated in rats. The concomitant use of GSO3Na with thiopental sodium significantly
David Balchin et al.
Biophysical chemistry, 156(2-3), 153-158 (2011-05-03)
A C-terminal helix (α9) adjacent to the active site on each subunit is a structural feature unique to the alpha isoform of glutathione transferases which contributes to the catalytic and ligandin functions of the enzyme. The ionisation state of Tyr-9

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