565950

Sialyl Lewis x, Sodium Salt

Enzymatically prepared tetrasaccharide which acts as a minimal binding ligand for E-selectins.

• Synonym(s): Sialyl Lewis x, Sodium Salt, SLe ^x, Neu5Acα2,3Galβ1,4(Fucα1,3)GlcNAc, SLe^x, Neu5Acα2,3Galβ1,4(Fucα1,3)GlcNAc
• Empirical Formula (Hill Notation): C₃₁H₅₁N₂NaO₂₃
• CAS Number: 98603-84-0
• Molecular Weight: 842.73
• MDL number: MFCD00270073
• UNSPSC Code: 12352201
• NACRES: NA.79

Properties

• Quality Level: 100
• Assay: ≥95% (TLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: white
• solubility: water: 2 mg/mL
• shipped in: wet ice
• storage temp.: −20°C
• InChI: 1S/C31H52N2O23/c1-9-18(43)21(46)22(47)28(51-9)53-24(12(5-34)32-10(2)38)25(15(42)7-36)54-29-23(48)27(20(45)16(8-37)52-29)56-31(30(49)50)4-13(40)17(33-11(3)39)26(55-31)19(44)14(41)6-35/h5,9,12-29,35-37,40-48H,4,6-8H2,1-3H3,(H,32,38)(H,33,39)(H,49,50)/t9-,12-,13-,14+,15+,16+,17+,18+,19+,20-,21+,22-,23+,24+,25+,26+,27-,28-,29-,31-/m0/s1
• InChI key: LAQPKDLYOBZWBT-NYLDSJSYSA-N

Description

General description

Enzymatically prepared tetrasaccharide which acts as a minimal binding ligand for E-selectins. SLe^x reduces injury following ischemia and reperfusion and immune complex-induced acute lung injury in animal models. In both of these models, SLe^x is presumed to act by blocking E-selectin-mediated neutrophil recruitment to sites of inflammation.

Enzymatically prepared tetrasaccharide which acts as a minimal binding ligand for E-selectins. SLe^x reduces injury following ischemia, reperfusion and immune complex-induced acute lung injury in animal models. In both of these models, SLe^x is presumed to act by blocking E-selectin-mediated neutrophil recruitment to sites of inflammation.

Warning

Toxicity: Standard Handling (A)

Other Notes

Seekamp, A., et al. 1994. Am. J. Pathol.144, 592.
Mulligan, M.S., et al. 1993. J. Exp. Med.178, 623.
Ichikawa, Y., et al. 1992. J. Am. Chem. Soc. 114, 9283.
Lasky, L.A. 1992. Science 258, 964.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable