To clarify the mechanism of phenol toxicity, the radical-scavenging activity of 2- or 2,6-di-tert-butyl- and 2-methoxy-substituted phenols was investigated by combining two distinct approaches: first, the induction period method for methacrylate polymerization initiated by benzoyl peroxide or 2,2'-azobisisobutyronitrile; and secondly
Xenobiotica; the fate of foreign compounds in biological systems, 13(5), 319-326 (1983-05-01)
Single oral doses of the haemorrhagic antioxidant 2,4,6-tri-t-butylphenol (260 mg/kg) were well absorbed in the rat. Peak blood levels of this compound were reached in 15-60 min. The blood elimination half-lives were 18.2 min for the alpha-phase and 11.8 h
Chemical research in toxicology, 6(4), 413-416 (1993-07-01)
13-Hydroperoxyoctadeca-9,11,15-trienoic acid was reacted with a catalytic amount of 5,10,15,20-tetraphenyl-21H,23H-porphyrin iron(III) chloride in dichloromethane containing 2,4,6-tri-tert-butylphenol. The principal products were identified as 13-oxooctadeca-9,11,15-trienoic acid, 13-oxotrideca-9,11-dienoic acid, and a series of isomeric epoxyaryl ethers [9-(2,4,6-tri-tert-butylphenoxy)-12,13-epoxyoctadec-10-enoic acids and 11-(2,4,6-tri-tert-butylphenoxy)-12,13-epoxyoctadec-9-enoic acids]. The epoxyaryl
High-valent metal-oxo complexes are postulated as key intermediates for a wide range of enzymatic and synthetic processes. To gain an understanding of these processes, the reactivity of an isolated, well-characterized Mn(V)-oxo complex, (TBP8Cz)MnVO (1), (TBP8Cz = octakis(para-tert-butylphenyl)corrolazinato(3-)) has been examined.
The Journal of toxicological sciences, 16(4), 167-179 (1991-11-01)
In order to study the chronic toxicity of 2, 4, 6-tri-tert-butylphenol (TTBP), groups of 40 Slc: Wistar rats of either sex were fed diet containing 0, 30, 100, 300 or 1000 ppm of TTBP for up to 24 months. Hematological
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