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B1253

Sigma-Aldrich

Butylated hydroxyanisole

≥98.5%

Synonym(s):

2(3)-t-Butyl-4-hydroxyanisole, 2(3)-t-Butylhydroquinone monomethyl ether, BHA

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About This Item

Linear Formula:
(CH3)3CC6H3(OCH3)OH
CAS Number:
25013-16-5
Molecular Weight:
180.24
EC Number:
246-563-8
MDL number:
MFCD01779059
UNSPSC Code:
12352100
NACRES:
NA.22

vapor density

6.2 (vs air)

Assay

≥98.5%

form

powder

autoignition temp.

599 °F

mp

58-60 °C (lit.)

InChI

1S/C11H16O2/c1-11(2,3)9-7-8(13-4)5-6-10(9)12/h5-7,12H,1-4H3

InChI key

MRBKEAMVRSLQPH-UHFFFAOYSA-N

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General description

Butylated hydroxyanisole is mainly used as a synthetic antioxidant in food and cosmetics. It is being extensively studied for potential toxicity.

Application

  • Antioxidant peptides from silk protein: Research explores the purification of novel antioxidant peptides derived from Bombyx mori pupae, identifying potential antioxidant applications for butylated hydroxyanisole in the food and cosmetic industries (Chukiatsiri et al., 2024).
  • Industrial lubricant additive: The performance of olive oil-based blended esters with butylated hydroxyanisole is evaluated, showcasing its efficacy as an industrial lubricant additive and its optimization using response surface methodology (Thangaraj et al., 2024).
  • Environmental degradation studies: Investigates the degradation of butylated hydroxyanisole using advanced oxidation processes, providing insights into environmental safety and the compound′s stability in pharmaceutical and industrial applications (Shi et al., 2024).

Other Notes

Mixed isomers (minimum 90% 3-isomer/9% 2-isomer)

Pictograms

Environment
GHS09

Hazard Statements

H411

Precautionary Statements

P273 - P391 - P501

Hazard Classifications

Aquatic Chronic 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

241.9 °F - Pensky-Martens closed cup

Flash Point(C)

116.6 °C - Pensky-Martens closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Cytotoxicity of butylated hydroxyanisole and butylated hydroxytoluene in isolated rat hepatocytes
Thompson, David and Moldeus, Peter
Biochemical Pharmacology, 37(11), 2201-2207 (1988)
Toxicology and biochemistry of butylated hydroxyanisole and butylated hydroxytoluene.
A L Branen
Journal of the American Oil Chemists' Society, 52(2), 59-63 (1975-02-01)
Stefanie D Roth et al.
PloS one, 7(9), e44505-e44505 (2012-09-14)
Inefficient intracellular protein trafficking is a critical issue in the pathogenesis of a variety of diseases and in recombinant protein production. Here we investigated the trafficking of factor VIII (FVIII), which is affected in the coagulation disorder hemophilia A. We
Behrouz Hassannia et al.
The Journal of clinical investigation, 128(8), 3341-3355 (2018-06-26)
High-risk neuroblastoma is a devastating malignancy with very limited therapeutic options. Here, we identify withaferin A (WA) as a natural ferroptosis-inducing agent in neuroblastoma, which acts through a novel double-edged mechanism. WA dose-dependently either activates the nuclear factor-like 2 pathway
Bhupendra Singh et al.
Carcinogenesis, 33(1), 156-163 (2011-11-11)
Exact mechanisms underlying the initiation and progression of estrogen-related cancers are not clear. Literature, evidence and our studies strongly support the role of estrogen metabolism-mediated oxidative stress in estrogen-induced breast carcinogenesis. We have recently demonstrated that antioxidants vitamin C and
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