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407771

Sigma-Aldrich

4-Ethoxy-1,1,1-trifluoro-3-buten-2-one

contains 0.5% BHT as stabilizer, technical grade

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About This Item

Linear Formula:
C2H5OCH=CHCOCF3
CAS Number:
Molecular Weight:
168.11
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22

grade

technical grade

form

liquid

contains

0.5% BHT as stabilizer

refractive index

n20/D 1.406 (lit.)

bp

51-53 °C/12 mmHg (lit.)

density

1.18 g/mL at 25 °C (lit.)

storage temp.

2-8°C

SMILES string

CCO\C=C\C(=O)C(F)(F)F

InChI

1S/C6H7F3O2/c1-2-11-4-3-5(10)6(7,8)9/h3-4H,2H2,1H3/b4-3+

InChI key

YKYIFUROKBDHCY-ONEGZZNKSA-N

General description

4-Ethoxy-1,1,1-trifluoro-3-buten-2-one reacts with phenylmagnesium bromide to afford ethoxy group substitution products, while it reacts with organozinc compounds to yield products arising from 1,2-addition to the carbonyl group. 4-Ethoxy-1,1,1-trifluoro-3-buten-2-one on heating with triethyl phosphite affords [4+2] cycloaddition product, 2,2,2-triethoxy 2,3-dihydro-3-ethoxy-5-trifluoromethyl-1,2λ5-oxaphospholene, which on hydrolysis affords a 2-oxo-2-hydroxy-2, 3-dihydro-3-hydroxy 5-trifluoromethyl-1,2λ5-oxaphospholen. It reacts with amino to give the N-protected amino acids, which is useful for the peptide synthesis.

Application

4-Ethoxy-1,1,1-trifluoro-3-buten-2-one may be used in the synthesis of 4-dialkylamino-1,1,1-trifluorobut-3-ene-2-ones. It may be used for the synthesis of β-alkyl- or dialkylamino substituted enones bearing a CF3 group.

Pictograms

FlameHealth hazard

Signal Word

Warning

Hazard Statements

Hazard Classifications

Aquatic Chronic 3 - Carc. 2 - Flam. Liq. 3

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point(F)

125.6 °F - closed cup

Flash Point(C)

52 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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4-Ethoxy-1, 1, 1-trifluoro-3-buten-2one as a new protecting reagent in peptide synthesis.
Gorbunova MG, et al.
Synthesis, 3, 207-209 (1991)
Synthesis of Trifluoromethylpyrroles and Related Heterocycles from 4-Ethyloxy-1, 1, 1-trifluorobut-3-ene-2-one.
Andrew RJ and Mellor JM.
Tetrahedron, 56(37), 7267-7272 (2000)
The interaction of 4-ethoxy-1, 1, 1-trifluoro-3-buten-2-one with C-nucleophiles-organo-magnesium and-zinc compounds
Gorbunova MG, et al.
Journal of Fluorine Chemistry, 65(1), 25-28 (1993)
The interaction of 4-ethoxy-1, 1, 1-trifluoro-3-buten-2-one with triethyl phosphite.
Gerus II, et al.
Journal of Fluorine Chemistry, 90(1), 1-3 (1998)
Preparation of α, β-unsaturated ketones bearing a trifluoromethyl group and their application in organic synthesis.
Nenajdenko VG, et al.
Molecules (Basel), 2(12), 186-232 (1997)

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