Skip to Content
Merck
All Photos(1)

Key Documents

View All Documentation

SML3933

Sigma-Aldrich

CLC-2 channel inhibitor, AK-42

≥98% (HPLC)

Synonym(s):

2-[[2,6-Dichloro-3-(phenylmethoxy)phenyl]amino]-3-pyridinecarboxylic acid, AK-42

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C19H14Cl2N2O3
CAS Number:
2408824-56-4
Molecular Weight:
389.23
UNSPSC Code:
12352200

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

SMILES string

O=C(C1=C(NC2=C(Cl)C=CC(OCC3=CC=CC=C3)=C2Cl)N=CC=C1)O

InChI

1S/C19H14Cl2N2O3/c20-14-8-9-15(26-11-12-5-2-1-3-6-12)16(21)17(14)23-18-13(19(24)25)7-4-10-22-18/h1-10H,11H2,(H,22,23)(H,24,25)

InChI key

AYGDOYFDJDUPSS-UHFFFAOYSA-N

Biochem/physiol Actions

Specific and potent CLC-2 chloride channel inhibitor that binds to the CLC-2 channel extracellularly.



CLC-2 channel inhibitor AK-42 is a specific and potent CLC-2 chloride channel inhibitor that binds to the CLC-2 channel extracellularly. AK-42 causes selective and reversible blocking of CLC-2 currents.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000367828
0000367830
0000349272
0000349272
0000367830

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Apurva A Oak et al.
Molecular pharmacology, 102(2), 106-115 (2022-06-10)
Loss of prosecretory Cl- channel CFTR activity is considered as the key cause of gastrointestinal disorders in cystic fibrosis including constipation and meconium ileus. Clc-2 is proposed as an alternative Cl- channel in intestinal epithelia that can compensate for CFTR
Anna K Koster et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(51), 32711-32721 (2020-12-06)
CLC-2 is a voltage-gated chloride channel that is widely expressed in mammalian tissues. In the central nervous system, CLC-2 appears in neurons and glia. Studies to define how this channel contributes to normal and pathophysiological function in the central nervous
Cryo-EM structures of ClC-2 chloride channel reveal the blocking mechanism of its specific inhibitor AK-42
Nature Communications, 14(1), 3424-3424 (2023)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service