SML2160

R-568 hydrochloride

≥95% (HPLC)

• Synonym(s): 2-chloro-N-[(1R)-1-(3-methoxyphenyl)ethyl]-benzenepropanamine hydrochloride (1:1), KRN 568 hydrochloride, NPS-R 568 hydrochloride, Norcalcin hydrochloride, R 568 hydrochloride, Tecalcet hydrochloride
• Empirical Formula (Hill Notation): C₁₈H₂₂ClNO · HCl
• CAS Number: 177172-49-5
• Molecular Weight: 340.29
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD16038895
• Assay: ≥95% (HPLC)
• Form: powder
• Storage condition: desiccated

Properties

• assay: ≥95% (HPLC)
• form: powder
• optical activity: [α]/D +35 to +40°, c = 0.5 in chloroform-d
• storage condition: desiccated
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear (warmed)
• storage temp.: 2-8°C
• SMILES string: C[C@@H](NCCCC1=C(C=CC=C1)Cl)C2=CC=CC(OC)=C2.Cl
• InChI: 1S/C18H22ClNO.ClH/c1-14(16-8-5-10-17(13-16)21-2)20-12-6-9-15-7-3-4-11-18(15)19;/h3-5,7-8,10-11,13-14,20H,6,9,12H2,1-2H3;1H/t14-;/m1./s1
• InChI key: YJXUXANREVNZLH-PFEQFJNWSA-N

Description

Biochem/physiol Actions

Calcium-sensing receptor (CaSR) allosteric agonist; calcimimetic

R-568 is a positive allosteric modulator of the calcium-sensing receptor (CaSR), increasing the sensitivity to activation by extracellular Ca²⁺. In rats, orally administered R-568 decreases plasma levels of PTH and Ca²⁺ and, at higher doses, increases plasma levels of calcitonin.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable