SML1672

JT010

≥98% (HPLC)

• Synonym(s): 2-Chloro-N-(4-(4-methoxyphenyl)thiazol-2-yl)-N-(3-methoxypropyl)-acetamide
• Empirical Formula (Hill Notation): C₁₆H₁₉ClN₂O₃S
• CAS Number: 917562-33-5
• Molecular Weight: 354.85
• UNSPSC Code: 12352200
• PubChem Substance ID: 329826007
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 10 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: O=C(N(C1=NC(C2=CC=C(OC)C=C2)=CS1)CCCOC)CCl
• InChI: 1S/C16H19ClN2O3S/c1-21-9-3-8-19(15(20)10-17)16-18-14(11-23-16)12-4-6-13(22-2)7-5-12/h4-7,11H,3,8-10H2,1-2H3
• InChI key: KZMAWJRXKGLWGS-UHFFFAOYSA-N

Description

Biochem/physiol Actions

JT010 is a non-cytotoxic and highly stable (>90% remains after 2 h in 1 mM DTT or 2-mercaptoethanol) chloroacetamido warhead-carrying thiazole derivative that acts as a potent and TRPA1-selective channel activator via covalent modification of TRPA1 active site Cys621. JT0101 stimulates calcium influx in TRPA1-transfected HEK293 cells in a dose-dependent manner (EC₅₀ = 650 pM) with excellent selectivity over TRPV1, TRPV3, TRPV4, TRPM2, TRPM8, and TRPC5 channels (EC₅₀ >1 μM).

JT010 is a non-cytotoxic and highly stable chloroacetamido warhead-carrying thiazole derivative.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable