SML0409

STF-083010

≥98% (HPLC)

• Synonym(s): N-[(2-Hydroxy-1-naphthalenyl)methylene]-2-thiophenesulfonamide
• Empirical Formula (Hill Notation): C₁₅H₁₁NO₃S₂
• CAS Number: 307543-71-1
• Molecular Weight: 317.38
• NACRES: NA.77
• PubChem Substance ID: 329825404
• UNSPSC Code: 12352200
• MDL number: MFCD02332975
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: light yellow to yellow-green
• solubility: DMSO: 5 mg/mL (clear solution)
• storage temp.: −20°C
• SMILES string: OC1=C(/C=N/S(C2=CC=CS2)(=O)=O)C3=C(C=CC=C3)C=C1
• InChI: 1S/C15H11NO3S2/c17-14-8-7-11-4-1-2-5-12(11)13(14)10-16-21(18,19)15-6-3-9-20-15/h1-10,17H/b16-10+
• InChI key: TVIVJHZHPKNDAQ-MHWRWJLKSA-N

Description

Application

STF-083010 has been used:

• in a study to investigate the potential anti-lipotoxic effect of nicotinamide and to elucidate underlying mechanism(s)
• as IRE1a inhibitor to study its effect on NOS 2 expression and investigate the underlying mechanisms in proinflammatory gene expression in astrocytes
• to block endogenous XBP1 cleavage for one hour prior to palmitate exposure in order to examine whether inositol?requiring enzyme 1α (IRE1α ) activation is implicated in palmitate cytotoxicity

Biochem/physiol Actions

STF-083010 is a potent inhibitor of IRE-1 mRNA splicing activity.

STF-083010 is a potent inhibitor of the ER transmembrane protein IRE1, which mediates the unfolded protein response. STF-083010 inhibits IRE1 endonuclease and mRNA splicing activity in response to endopasmic reticulum (ER) stress, but has no affect on the kinase activity of IRE1.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable