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P9625

Sigma-Aldrich

Phenazine methosulfate

powder, electron acceptor

Synonym(s):

5-Methylphenazinium methyl sulfate, N-Methylphenazonium methyl sulfate, PMS

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About This Item

Linear Formula:
C13H11N2 · CH3SO4
CAS Number:
Molecular Weight:
306.34
Beilstein:
3898869
EC Number:
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77

product name

Phenazine methosulfate,

form

powder

Quality Level

λ

0.01 g/L in H2O, 1 cm path

UV absorption

λ: 387.5 nm Amax

antibiotic activity spectrum

fungi

Mode of action

DNA synthesis | interferes
cell membrane | interferes

storage temp.

−20°C

SMILES string

COS([O-])(=O)=O.C[n+]1c2ccccc2nc3ccccc13

InChI

1S/C13H11N2.CH4O4S/c1-15-12-8-4-2-6-10(12)14-11-7-3-5-9-13(11)15;1-5-6(2,3)4/h2-9H,1H3;1H3,(H,2,3,4)/q+1;/p-1

InChI key

RXGJTUSBYWCRBK-UHFFFAOYSA-M

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General description

Phenazines are heterocyclic compounds produced as secondary metabolites by bacteria.

Application

Phenazine methosulfate is used with ascorbic acid to determine nitric oxide reductase activity.
Phenazine methosulfate has been used:
  • as a component of succinate dehydrogenase enzyme substrate solution
  • to induce superoxide radical generation in red blood cell suspensions and to study its influence on RBC deformability
  • as a component of complex II histochemistry media

Biochem/physiol Actions

Phenazine m ethosulfate (PMS) acts as a good electron acceptor. PMS is reduced non-enzymatically by (nicotinamide adenine dinucleotide) NADH and (nicotinamide adenine dinucleotide phosphate) NADPH.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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María Gabriela Villamizar-Sarmiento et al.
Nanomaterials (Basel, Switzerland), 9(7) (2019-07-03)
We report on the design, development, characterization, and a preliminary cellular evaluation of a novel solid material. This material is composed of low-molecular-weight hyaluronic acid (LMWHA) and polyarginine (PArg), which generate aqueous ionic nanocomplexes (INC) that are then freeze-dried to
Duong Luong et al.
Materials science & engineering. C, Materials for biological applications, 103, 109759-109759 (2019-07-28)
Transition metals (TM) are essential microelements with various biological functions demanded in tissue regeneration applications. Little is known about therapeutic potential of TM within soft hydrogel biomaterials. The soluble divalent TM, such as Zn, Cu, Mn and Co, were stably
Richard Y Wu et al.
Microbiome, 5(1), 135-135 (2017-10-12)
Prebiotics are non-digestible food ingredients that enhance the growth of certain microbes within the gut microbiota. Prebiotic consumption generates immune-modulatory effects that are traditionally thought to reflect microbial interactions within the gut. However, recent evidence suggests they may also impart
Assessment of oxidant susceptibility of red blood cells in various species based on cell deformability
Simmonds MJ, et al.
Biorheology, 48(5-6), 293-304 (2011)
Handbook on Clostridia, , pages=, 84-84 (2005)

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