P6188

Prostaglandin I₂ sodium salt

≥96% (HPLC), synthetic, powder

• Synonym(s): (5Z,9α,11α,13E,15S)-6,9-Epoxy-11,15-dihydroxyprosta-5,13-dien-1-oic acid sodium salt, Epoprostenol sodium salt, PGI₂-Na, Prostacyclin sodium salt
• Empirical Formula (Hill Notation): C₂₀H₃₁NaO₅
• CAS Number: 61849-14-7
• Molecular Weight: 374.45
• Beilstein: 6472195
• EC Number: 263-273-7
• UNSPSC Code: 12352401
• eCl@ss: 42020658
• PubChem Substance ID: 24898653
• NACRES: NA.77

Properties

• biological source: synthetic
• Assay: ≥96% (HPLC)
• form: powder
• color: white to off-white
• solubility: H₂O: 1 mg/mL (Hydrolyzes to 6-ketoprostaglandin F_1α in aqueous solution.); ethanol: 50 mg/mL
• functional group: carboxylic acid; hydroxyl
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C[C@@](O/2)([H])[C@]1([H])CC2=C\CCCC(O)=O.[Na]
• InChI: 1S/C20H32O5.Na/c1-2-3-4-8-15(21)10-11-16-17(22)12-18-20(16)14(13-25-18)7-5-6-9-19(23)24;/h7,10-11,15-18,20-22H,2-6,8-9,12-13H2,1H3,(H,23,24);/q;+1/p-1/b11-10+,14-7-;/t15-,16-,17+,18-,20+;/m0./s1
• InChI key: OURCVRVJQMLUNA-QFDVFERUSA-M

Description

Application

Prostaglandin I2 sodium salt has been used:

• in the preparation of stock solution for platelet washing procedure
• as supplement in platelet-rich-plasma, for platelet preparation
• to prevent platelet activation

Biochem/physiol Actions

Prostacyclin is a short-lived product of the cyclooxygenase pathway in vascular endothelial cells. It is a potent inhibitor of platelet aggregation by antagonizing thromboxane A₂ and stimulating platelet adenylyl cyclase. Nitric oxide is also produced in vascular endothelium where it inhibits platelet aggregation, regulates inducible cyclooxygenase production, and may work synergistically with prostacyclin to attenuate the thrombotic process. Prostacyclin is vasoprotective, protecting arterial walls from injury-induced lesions and cytoprotective in the liver and gastrointestinal tract.

Prostacyclin therapy improves hemodynamics in pulmonary arterial hypertension.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves