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M3324

Sigma-Aldrich

M100907

≥98% (HPLC)

Synonym(s):

(R)-(+)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-pipidinemethanol, MDL100907, Volinanserin

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About This Item

Empirical Formula (Hill Notation):
C22H28FNO3
CAS Number:
139290-65-6
Molecular Weight:
373.46
MDL number:
MFCD00909060
UNSPSC Code:
12352200
PubChem Substance ID:
329817971
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

off-white to light brown

solubility

DMSO: ≥20 mg/mL

storage temp.

2-8°C

SMILES string

COc1cccc([C@H](O)C2CCN(CC2)CCc3ccc(F)cc3)c1OC

InChI

1S/C22H28FNO3/c1-26-20-5-3-4-19(22(20)27-2)21(25)17-11-14-24(15-12-17)13-10-16-6-8-18(23)9-7-16/h3-9,17,21,25H,10-15H2,1-2H3/t21-/m1/s1

InChI key

HXTGXYRHXAGCFP-OAQYLSRUSA-N

Gene Information

human ... HTR2A(3356)

General description

M100907 blocks the serotonin 2A (5-HT2A) receptors and imposes antidepressant-like effects. It may be used for treating dopaminergic anomalies.

Biochem/physiol Actions

M100907 is a selective 5-HT2A Antagonist.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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The selective 5-HT 2A receptor antagonist M100907 enhances antidepressant-like behavioral effects of the SSRI fluoxetine
Marek GJ, et al.
Neuropsychopharmacology, 30(12), 2205-2205 (2005)
Kathryn A Cunningham et al.
ACS chemical neuroscience, 4(1), 110-121 (2013-01-22)
Relapse to cocaine dependence, even after extended abstinence, involves a number of liability factors including impulsivity (predisposition toward rapid, unplanned reactions to stimuli without regard to negative consequences) and cue reactivity (sensitivity to cues associated with cocaine-taking which can promote
Paul J Fletcher et al.
Neuropharmacology, 62(7), 2288-2298 (2012-02-22)
The reinforcing effects of nicotine are mediated in part by brain dopamine systems. Serotonin, acting via 5-HT(2A) and 5-HT(2C) receptors, modulates dopamine function. In these experiments we examined the effects of the 5-HT(2C) receptor agonist Ro60-0175 and the 5-HT(2A) receptor
Ragy R Girgis et al.
Psychiatry research, 194(3), 230-234 (2011-11-15)
Evidence from biochemical, imaging, and treatment studies suggest abnormalities of the serotonin system in autism spectrum disorders, in particular in frontolimbic areas of the brain. We used the radiotracers [(11)C]MDL 100907 and [(11)C]DASB to characterize the 5-HT(2A) receptor and serotonin
Meaghan Creed-Carson et al.
Behavioural brain research, 219(2), 273-279 (2011-01-26)
An important limitation of classical antipsychotic drugs such as haloperidol (HAL) is their liability to induce extrapyramidal motor symptoms acutely and tardive dyskinetic syndromes when given chronically. These effects are less likely to occur with newer antipsychotic drugs, an attribute
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