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H9291

Sigma-Aldrich

Hemopexin from human plasma

≥95% (SDS-PAGE), lyophilized powder

Synonym(s):

HPX, HX, Hpxn, beta-1B-glycoprotein

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About This Item

CAS Number:
UNSPSC Code:
12352202
NACRES:
NA.61

biological source

human plasma

Quality Level

Assay

≥95% (SDS-PAGE)

form

lyophilized powder

mol wt

~57 kDa

technique(s)

microbiological culture: suitable

NCBI accession no.

storage temp.

−20°C

Gene Information

human ... HPX(3263)

General description

Hemopexin (HPX) is produced by cells of the central nervous system. It is a 60 kDa serum glycoprotein.

Application

Hemopexin from human plasma has been used S. aureus surface colonization assay. It has also been used to stimulate mixed lymphocyte cells to determine the biomarkers in acute rejection.

Biochem/physiol Actions

Hemopexin is an acute-phase protein that plays a major protective role against oxidative stress through its heme-scavenging activities. Hemopexin binds heme with high affinity and is critical for recycling the iron bound to heme molecules and for protecting against heme-induced cellular damage. Free heme, when released or lost from proteins like hemoglobin, can catalyze the formation of reactive oxygen species. Heme is lipophilic and interchelates into lipid membranes and participate in the formation of highly-toxic hydroxyl radicals. Hemopexin may also protect against the heme-mediated oxidation of LDL cholesterol.

Hemopexin may also serve an anti-inflammatory role via the negative regulation of IL-6 and TNF-α secretion by activated macrophages.

Physical form

Lyophilized powder containing sodium phosphate, NaCl, and KCl, pH 7.4

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Paolo Ascenzi et al.
Biochemical and biophysical research communications, 428(2), 239-244 (2012-10-17)
Hemopexin (HPX) displays a pivotal role in heme scavenging and delivery to the liver. In turn, heme-Fe-hemopexin (HPX-heme-Fe) displays heme-based spectroscopic and reactivity properties. Here, kinetics and thermodynamics of cyanide binding to ferric and ferrous hexa-coordinate human plasma HPX-heme-Fe (HHPX-heme-Fe(III)
Yu-Hong Shi et al.
Dong wu xue yan jiu = Zoological research, 33(5), 481-486 (2012-09-29)
The warm temperature acclimation related 65 kDa protein-2 (Wap65-2), a teleost plasma glycoprotein, plays an important role in immune regulation against bacterial infection. Here, for the first time we determined the full length cDNA sequence of the Japanese sea bass
Zhengyang Wang et al.
Biochimica et biophysica acta, 1824(4), 692-700 (2012-02-14)
The pleural effusion proteome has been found containing information that directly reflects pathophysiological status and represents a potential diagnostic value for pulmonary diseases. However, the variability in protein composition between malignant and benign effusions is not well understood. Herein, we
Aubrey J Cunnington et al.
Journal of immunology (Baltimore, Md. : 1950), 189(11), 5336-5346 (2012-10-27)
It is not known why people are more susceptible to bacterial infections such as nontyphoid Salmonella during and after a malaria infection, but in mice, malarial hemolysis impairs resistance to nontyphoid Salmonella by impairing the neutrophil oxidative burst. This acquired
Kazuhiko Kawasaki et al.
European journal of oral sciences, 119 Suppl 1, 247-253 (2012-01-25)
Dental enamel is a hypermineralized tissue, containing only trace amounts of organic components. During enamel formation, matrix metalloproteinase 20 (MMP20) processes proteins comprising enamel matrix and facilitates hypermineralization. In the human genome, 24 distinct MMP genes have been identified. Among

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