A4888
Amphotericin B from Streptomyces sp.
~80% (HPLC), powder
Synonym(s):
LNS-AmB, NSC 527017, Fungizone
About This Item
biological source
Streptomyces sp.
Quality Level
Assay
~80% (HPLC)
form
powder
color
yellow to orange
solubility
DMF: 2-4 mg/mL
DMSO: 30-40 mg/mL
H2O: insoluble
water: insoluble
antibiotic activity spectrum
fungi
yeast
Mode of action
cell membrane | interferes
storage temp.
2-8°C
SMILES string
C[C@H]1O[C@@H](O[C@@H]2C[C@@H]3O[C@](O)(C[C@@H](O)C[C@@H](O)[C@H](O)CC[C@@H](O)C[C@@H](O)CC(=O)O[C@@H](C)[C@H](C)[C@H](O)[C@@H](C)\C=C\C=C\C=C\C=C\C=C\C=C\C=C\2)C[C@H](O)[C@H]3C(O)=O)[C@@H](O)[C@@H](N)[C@@H]1O
InChI
1S/C47H73NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-33(51)22-36(53)35(52)20-19-31(49)21-32(50)23-39(55)62-29(3)28(2)42(27)56/h5-18,27-38,40-44,46,49-54,56-58,61H,19-26,48H2,1-4H3,(H,59,60)/b6-5+,9-7+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28-,29-,30+,31+,32+,33-,34-,35+,36+,37-,38-,40+,41-,42+,43+,44-,46-,47+/m0/s1
InChI key
APKFDSVGJQXUKY-INPOYWNPSA-N
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General description
Application
Amphotericin B from Streptomyces sp. has been used-
- for amphotericin perforated patch technique
- as a reference antifungal drug during MIC (minimum inhibitory concentration) agar dilution assay
- as a component of Arcobacter selective isolation broth
Biochem/physiol Actions
Antimicrobial spectrum: Includes fungi and yeast
Features and Benefits
Preparation Note
Amphotericin B remains active for 3 days in culture at 37°C. At -20°C, and with protection from air and light, the product remains active for 5 years.
Storage and Stability
Other Notes
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
STOT RE 1
Storage Class Code
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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