51290
Hemoglobin from bovine blood
lyophilized, 2×cryst., ≥90% (SDS-PAGE), powder
Synonym(s):
Bovine hemoglobin, Hb, Methemoglobin
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About This Item
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biological source
bovine blood
Quality Level
Assay
≥90% (SDS-PAGE)
form
powder
quality
2×cryst.
lyophilized
mol wt
Mr ~64500
technique(s)
UV/Vis spectroscopy: suitable
impurities
salt, none detected
~0.3% Fe
loss
≤8% loss on drying
storage temp.
2-8°C
Gene Information
cow ... HBA1(281221) , HBB(280813) , HBE2(513240) , HBE4(513108) , HBG(511735) , alpha globin(512439)
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General description
Hemoglobin (Hb) is the protein responsible for storage and transport of oxygen and other gaseous ligands in red blood cells (RBC). Hb is also the pioneer material for synthesis of Hb-based oxygen carriers (HBOCs) that can be used as substitutes for RBC.
Application
The solubility of α-elastin has been applied to construction of elastin-mimetic biomaterials.
Biochem/physiol Actions
Oxygen transporter. The Fe2+/Fe3+ balance is a physiological indicator of blood oxygenation; deoxygenated hemoglobin accessorizes a feedback loop by reducing nitrite to NO, a vasodilator which enhances blood flow to oxygen-deprived tissues.
Caution
Since native hemoglobin is readily oxidized in air, these preparations may be predominantly methemoglobin.
Other Notes
Review: Oxygen carrier proteins
Sales restrictions may apply
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Paul W Buehler et al.
Biomaterials, 31(13), 3723-3735 (2010-02-13)
Hemoglobin-based oxygen carriers (HBOC) are currently being developed as red blood cell (RBC) substitutes for use in transfusion medicine. Despite significant commercial development, late stage clinical results of polymerized hemoglobin (PolyHb) solutions hamper development. We synthesized two types of PolyHbs
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