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401M-1

Sigma-Aldrich

TLE1 (1F5) Mouse Monoclonal Antibody

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

Quality Level

100
500

conjugate

unconjugated

antibody form

diluted ascites fluid

antibody product type

primary antibodies

clone

1F5, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (401M-14)
vial of 0.5 mL concentrate (401M-15)
bottle of 1.0 mL predilute (401M-17)
vial of 1.0 mL concentrate (401M-16)
bottle of 7.0 mL predilute (401M-18)

manufacturer/tradename

Cell Marque™

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:10-1:50

isotype

IgG2a

control

synovial sarcoma

shipped in

wet ice

storage temp.

2-8°C

visualization

nuclear

Gene Information

human ... TLE1(7088)

General description

Transducin-like enhancer protein 1 (TLE1) is a protein encoded by the gene TLE1 and is involved in the control of hematopoiesis, neuronal, and terminal epithelial differentiation. Positive immunohistochemical nuclear staining with anti-TLE1 has been shown to be useful for identifying synovial sarcoma. TLE1 expression may also be observed in other soft tissue neoplasms, usually at low levels.

Quality


IVD
IVD
IVD
RUO

Linkage

TLE1 Positive Control Slides, Product No. 401S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Certificates of Analysis (COA)

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Marc El Beaino et al.
Sarcoma, 2020, 7192347-7192347 (2020-04-24)
Synovial sarcoma can present morphologically in multiple forms, including biphasic and monophasic subtypes. As a result, the histological diagnosis can sometimes be challenging. Transducin-Like Enhancer 1 (TLE1) is a transcriptional corepressor that normally is involved in embryogenesis and hematopoiesis but
Kemal Kosemehmetoglu et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 22(7), 872-878 (2009-04-14)
TLE1, a transcriptional repressor essential in hematopoiesis, neuronal differentiation and terminal epithelial differentiation, has recently been shown in a single tissue microarray study to be a highly sensitive and relatively specific marker of synovial sarcomas. Expression of TLE1 has not
Jefferson Terry et al.
The American journal of surgical pathology, 31(2), 240-246 (2007-01-27)
Synovial sarcoma is a soft tissue malignancy defined by the SYT-SSX fusion oncogene. Demonstration of the t(X;18) by cytogenetics, fluorescence in situ hybridization or reverse-transcriptase polymerase chain reaction has become the gold standard for diagnosis, but practical considerations limit the
Amanda Jagdis et al.
The American journal of surgical pathology, 33(12), 1743-1751 (2009-10-08)
Synovial sarcoma is a high-grade soft tissue sarcoma that can be challenging to diagnose on the basis of histology alone. It is defined by a characteristic translocation t(X;18) that produces the fusion oncogene SYT-SSX. The current diagnostic gold standard for

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