Skip to Content
Merck
All Photos(1)

Key Documents

07858

Sigma-Aldrich

(R)-(−)-3-Amino-1-Boc-piperidine

≥98.0% (TLC)

Synonym(s):

(R)-1-Boc-3-piperidinamine, tert-Butyl (R)-3-amino-1-piperidinecarboxylate

Sign Into View Organizational & Contract Pricing


About This Item

Empirical Formula (Hill Notation):
C10H20N2O2
CAS Number:
Molecular Weight:
200.28
MDL number:
UNSPSC Code:
12352005
PubChem Substance ID:
NACRES:
NA.22

Quality Level

Assay

≥98.0% (TLC)

optical activity

[α]/D -28.5±2°, c = 1 in DMF

SMILES string

CC(C)(C)OC(=O)N1CCC[C@@H](N)C1

InChI

1S/C10H20N2O2/c1-10(2,3)14-9(13)12-6-4-5-8(11)7-12/h8H,4-7,11H2,1-3H3/t8-/m1/s1

InChI key

AKQXKEBCONUWCL-MRVPVSSYSA-N

General description

(R)-3-Amino-1-Boc-piperidine can be used as a precursor for the preparation of dipeptidyl peptidase IV inhibitors like linagliptin, alogliptin, and other antidiabetic agents.

Application

(R)-3-Amino-1-Boc-piperidine can be used to prepare a benzoxazepine derivative named (R)-7-(3,5-dimethoxyphenyl)-N-(piperidin-3-yl)-4-propionyl-2,3,4,5-tetrahydro-1,4-benzoxazepine-9-carboxamide, a potent CBP/P300 bromodomain inhibitor.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Asymmetric synthesis of a high added value chiral amine using immobilized ω-transaminases
Petri A, et al.
Beilstein Journal of Organic Chemistry, 15(1), 60-66 (2019)
Development of selective CBP/P300 benzoxazepine bromodomain inhibitors
Popp TA, et al.
Journal of Medicinal Chemistry, 59(19), 8889-8912 (2016)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service