Key Documents

Pepstatin A, Synthetic

Name: Pepstatin A, Synthetic
Brand: MM

Pepstatin A, Synthetic, CAS 26305-03-3, is a reversible inhibitor of aspartic proteases. Inhibits cathepsin D, pepsin, and renin.

Synonym(s):

Pepstatin A, Synthetic, Iva-Val-Val-Sta-Ala-Sta, Isovaleryl-Val-Val-4-amino-3-hydroxy-6-methylheptanoyl-Ala-4-amino-3-hydroxy-6-methylheptanoic Acid

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About This Item

Empirical Formula (Hill Notation):

C₃₄H₆₃N₅O₉

CAS Number:

26305-03-3

Molecular Weight:

685.89

UNSPSC Code:

12352202

NACRES:

NA.77

MDL number:

MFCD00060740

Assay:

≥98% (HPLC)

Form:

solid

Storage condition:

OK to freeze

Pricing and availability is not currently available.

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Properties

description

Merck USA index - 14, 7147

Quality Segment

100

assay

≥98% (HPLC)

form

solid

optical activity

[α]20.0/D -90.0±5.0, c = 0.5 in methanol

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze

color

white

solubility

DMSO: 1 mg/mL, methanol: 1 mg/mL

storage temp.

2-8°C

SMILES string

N([C@@H](C(C)C)C(=O)NC(C(O)CC(=O)N[C@@H](C)C(=O)NC(C(O)CC(=O)O)CC(C)C)CC(C)C)C(=O)[C@@H](NC(=O)CC(C)C)C(C)C

InChI

1S/C34H63N5O9/c1-17(2)12-23(37-33(47)31(21(9)10)39-34(48)30(20(7)8)38-27(42)14-19(5)6)25(40)15-28(43)35-22(11)32(46)36-24(13-18(3)4)26(41)16-29(44)45/h17-26,30-31,40-41H,12-16H2,1-11H3,(H,35,43)(H,36,46)(H,37,47)(H,38,42)(H,39,48)(H,44,45)/t22-,23?,24?,25?,26?,30-,31-/m0/s1

InChI key

FAXGPCHRFPCXOO-JHTFMCFMSA-N

Description

General description

A reversible inhibitor of aspartic proteases. Inhibits cathepsin D, pepsin, and renin. Reported to block apoptosis induced by CA-074 (Cat. No. 508437).

Effective concentration: 1.0 µM.

Biochem/physiol Actions

EC50 = 1.0 µM in blocking apoptosis induced by CA-074 in PC12 cell lines

Primary Target
cathepsin D

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.

Other Notes

Isahara, K., et al. 1999. Neuroscience91, 233.
Kanamori, S., et al. 1998. Biochem. Biophys. Res. Commun.251, 204.
Szewczuk, Z., et al. 1992. Int. J. Pept. Prot. Res.40, 233.
Carraway, R.E., et al. 1991. Peptides12, 107.
Eid, M., et al. 1981. Biochem. J.197, 465.
Umezawa, H., et al. 1970. J. Antibiot.23, 259.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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This Item	110175-M	PEPS-RO	516483
Sigma-Aldrich 516481-M Pepstatin A, Synthetic	Millipore 110175-M Acetyl-Pepstatin	Roche PEPS-RO Pepstatin	Sigma-Aldrich 516483 Pepstatin A, Penetratin
assay ≥98% (HPLC)	assay ≥97% (HPLC)	assay -	assay ≥97% (HPLC)
form solid	form solid	form lyophilized	form lyophilized solid
Quality Level 100	Quality Level 100	Quality Level -	Quality Level 100
manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename Roche	manufacturer/tradename Calbiochem^®
storage temp. 2-8°C	storage temp. −20°C	storage temp. 2-8°C	storage temp. −20°C
solubility DMSO: 1 mg/mL, methanol: 1 mg/mL	solubility 50% acetic acid: 5 mg/mL	solubility ethanol: 1 mg/mL, methanol: 1 mg/mL, acetic acid: soluble 300 μg/mL (6N), pyridine: soluble, water: insoluble	solubility water: 1 mg/mL

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c