Skip to Content
Merck
All Photos(2)

Key Documents

700034P

Avanti

7α-hydroxycholesterol

Avanti Research - A Croda Brand

Synonym(s):

cholest-5-ene-3b,7a-diol; 110808

Sign Into View Organizational & Contract Pricing


About This Item

Empirical Formula (Hill Notation):
C27H46O2
CAS Number:
Molecular Weight:
402.65
UNSPSC Code:
12352211
NACRES:
NA.25

description

cholest-5-en-3β,7α-diol

Assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 10 mg (700034P-10mg)
pkg of 1 × 5 mg (700034P-5mg)
pkg of 1 × 50 mg (700034P-50mg)

manufacturer/tradename

Avanti Research - A Croda Brand

shipped in

dry ice

storage temp.

−20°C

InChI

1S/C27H46O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h16-18,20-25,28-29H,6-15H2,1-5H3/t18-,20+,21-,22+,23+,24-,25+,26+,27-/m1/s1

InChI key

OYXZMSRRJOYLLO-RVOWOUOISA-N

General description

7a-hydroxy-cholesterol is a B-ring substituted oxysterol.

Application


  • Bile acid synthesis, modulation, and dementia: A metabolomic, transcriptomic, and pharmacoepidemiologic study.: This research investigated the relationship between bile acid metabolism and dementia through a comprehensive approach integrating metabolomics, transcriptomics, and pharmacoepidemiology. The findings suggest that alterations in bile acid synthesis may be linked to the pathogenesis of dementia (Varma et al., 2021).

Packaging

5 mL Amber Glass Screw Cap Vial (700034P-10mg)
5 mL Amber Glass Screw Cap Vial (700034P-50mg)
5 mL Amber Glass Screw Cap Vial (700034P-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Michael E Abrams et al.
Nature microbiology, 5(7), 929-942 (2020-04-15)
Cholesterol 25-hydroxylase (CH25H) is an interferon-stimulated gene that converts cholesterol to the oxysterol 25-hydroxycholesterol (25HC). Circulating 25HC modulates essential immunological processes including antiviral immunity, inflammasome activation and antibody class switching; and dysregulation of CH25H may contribute to chronic inflammatory disease
Mustafa Yalcinkaya et al.
Journal of lipid research, 61(4), 492-504 (2020-01-08)
Loss of pancreatic β-cell mass and function as a result of sustained ER stress is a core step in the pathogenesis of diabetes mellitus type 2. The complex control of β-cells and insulin production involves hedgehog (Hh) signaling pathways as

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service