W381918

L-Arginine

99%, FCC, FG

• Synonym(s): (S)-2-Amino-5-guanidinopentanoic acid
• Linear Formula: H₂NC(=NH)NH(CH₂)₃CH(NH₂)CO₂H
• CAS Number: 74-79-3
• Molecular Weight: 174.20
• FEMA Number: 3819
• Beilstein: 1725413
• EC Number: 200-811-1
• MDL number: MFCD00002635
• UNSPSC Code: 12164502
• eCl@ss: 32160406
• PubChem Substance ID: 24901894
• Flavis number: 17.003
• NACRES: NA.21

Properties

• biological source: synthetic
• Quality Level: 400
• grade: FG
• Agency: meets purity specifications of JECFA
• reg. compliance: EU Regulation 1334/2008 & 872/2012; FCC; FDA 21 CFR 172.320
• Assay: 99%
• form: powder or crystals
• optical activity: [α]20/D +27°, c = 8 in 6 M HCl
• mp: 222 °C (dec.) (lit.)
• application(s): flavors and fragrances
• Documentation: see Safety & Documentation for available documents
• food allergen: no known allergens
• Organoleptic: faint
• SMILES string: N[C@@H](CCCNC(N)=N)C(O)=O
• InChI: 1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/t4-/m0/s1
• InChI key: ODKSFYDXXFIFQN-BYPYZUCNSA-N
• Gene Information: human ... NOS1(4842) , NOS2(4843) ; rat ... Ppm1a(24666)

Description

General description

L-Arginine is an amino acid that plays a key role in many physiological processes such as tissue repair and reproduction. It is a key precursor for synthesizing nitric oxide in mammals. Due to these factors, the dietary supplementation with L-arginine may show a range of health benefits.

Application

• Metabolomic approaches to dissect dysregulated metabolism in the progression of pre-diabetes to T2DM.: This study employs L-Arginine to examine metabolic changes during the transition from pre-diabetes to type 2 diabetes mellitus, offering new targets for early intervention (Ji et al., 2024 Jun). Link to the article.


• Amino acid profile alteration in age-related atrial fibrillation.: Investigates the role of L-Arginine in cardiovascular aging, highlighting its potential in developing therapeutic strategies against atrial fibrillation associated with aging (Huang et al., 2024 Mar). Link to the article.

Biochem/physiol Actions

Substrate of nitric oxide synthase, which is converted to citrulline and nitric oxide (NO). Induces insulin release by a nitric oxide-dependent mechanism.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves