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33097-U

Supelco

trimethylanilinium hydroxide (TMAH)

0.2 M in methanol

Synonym(s):

Trimethylphenylammonium hydroxide solution, Phenyltrimethylammonium hydroxide, TMAH

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About This Item

Linear Formula:
(CH3)3N(OH)C6H5
CAS Number:
1899-02-1
Molecular Weight:
153.22
Beilstein:
3917033
MDL number:
MFCD00041899
UNSPSC Code:
12000000
PubChem Substance ID:
329754455

grade

for GC derivatization

reaction suitability

reagent type: derivatization reagent
reaction type: Esterifications

packaging

pkg of 1 × 10 mL (33097-U)

concentration

0.2 M in methanol

SMILES string

[OH-].C[N+](C)(C)c1ccccc1

InChI

1S/C9H14N.H2O/c1-10(2,3)9-7-5-4-6-8-9;/h4-8H,1-3H3;1H2/q+1;/p-1

InChI key

HADKRTWCOYPCPH-UHFFFAOYSA-M

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General description

Trimethylanilinium hydroxide (TMAH) is an alkylating agent, which is effectively used esterification of carboxylic acids, etherfication of alcohols and N-alkylation of amino groups.

Application

It is used to derivatize the serum sample for determination of Topiramate in Epileptic patients using GC-MS analysis.

Other Notes

Reagent for carboxylic acid methyl ester, methyl esters.

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Dam. 1 - Flam. Liq. 2 - Skin Irrit. 2 - STOT SE 1

Target Organs

Eyes

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point(F)

51.8 °F - closed cup

Flash Point(C)

11 °C - closed cup

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Certificates of Analysis (COA)

Lot/Batch Number
LC23665V
LC19061V
LC16326V
LC15133
LC12701

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Vladimir Zaikin, John M. Halket
A Handbook of Derivatives for Mass Spectrometry, 218-219 (2009)
E.W. Robb and J.J. Westbrook III
Analytical Chemistry, 35, 1644-1644 (1963)
A capillary GC method using nitrogen phosphorus detection for determination of topiramate in patients with epilepsy.
Malakova, J., et al.
Chromatographia, 66, 363-367 (2007)
Anthony A Mikulec et al.
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 30(2), 131-138 (2009-01-31)
Drugs applied to the middle ear enter perilymph through the bony otic capsule. Drugs applied intratympanically in humans are thought to enter the cochlea primarily through the round window membrane (RWM). Local drug treatments of the ear are commonly evaluated
Alec N Salt et al.
Journal of the Association for Research in Otolaryngology : JARO, 13(6), 771-783 (2012-09-13)
Perilymph pharmacokinetics was investigated by a novel approach, in which solutions containing drug or marker were injected from a pipette sealed into the perilymphatic space of the lateral semi-circular canal (LSCC). The cochlear aqueduct provides the outlet for fluid flow
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