T2891
Tryptamine
≥99%, crystalline
Synonym(s):
2-(3-Indolyl)ethylamine, 3-(2-Aminoethyl)indole
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About This Item
Empirical Formula (Hill Notation):
C10H12N2
CAS Number:
Molecular Weight:
160.22
Beilstein:
125513
EC Number:
MDL number:
UNSPSC Code:
12352100
Recommended Products
Assay
≥99%
form
crystalline
color
white
bp
137 °C/0.15 mmHg (lit.)
mp
113-116 °C (lit.)
storage temp.
−20°C
SMILES string
NCCc1c[nH]c2ccccc12
InChI
1S/C10H12N2/c11-6-5-8-7-12-10-4-2-1-3-9(8)10/h1-4,7,12H,5-6,11H2
InChI key
APJYDQYYACXCRM-UHFFFAOYSA-N
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Biochem/physiol Actions
Vasoactive; may have a neuromodulator function; biogenic amine formed from the decarboxylation of tryptophan by L-aromatic amino acid decarboxylase.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1 - Skin Sens. 1A
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
365.0 °F - closed cup
Flash Point(C)
185 °C - closed cup
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Tryptamine may couple dopaminergic and serotonergic transmission in the brain.
A V Juorio et al.
General pharmacology, 21(5), 613-616 (1990-01-01)
D D Mousseau
Metabolic brain disease, 8(1), 1-44 (1993-03-01)
Although early interest in the biomedical relevance of tryptamine has waned in recent years, it is clear from the above discussion that the study of tryptamine is worthy of serious consideration as a factor in neuropsychiatric disorders. The study of
A J Greenshaw
Progress in neuro-psychopharmacology & biological psychiatry, 13(3-4), 431-443 (1989-01-01)
1. The relevance of trace amine research is outlined for PEA and T in the context of psychotherapeutic drug action, particularly in relation to the actions of MAO-inhibitor antidepressant drugs. 2. Evidence for the neuronal localization of these amines and
6-halogenochromones bearing tryptamine: one-step access to potent and highly selective inhibitors of breast cancer resistance protein.
Glaucio Valdameri et al.
ChemMedChem, 7(7), 1177-1180 (2012-05-23)
Gabriele Loers et al.
Journal of neurochemistry, 128(1), 88-100 (2013-08-21)
Polysialic acid (PSA) is a major regulator of cell-cell interactions in the developing nervous system and in neural plasticity in the adult. As a polyanionic molecule with high water-binding capacity, PSA increases the intercellular space generating permissive conditions for cell
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