SML3766
SRI-42127
≥98% (HPLC)
Synonym(s):
3-(1H-Indazol-6-yl)-N-methyl-N-(tetrahydro-2H-pyran-4-yl)imidazo[1,2-b]pyridazin-6-amine
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About This Item
Empirical Formula (Hill Notation):
C19H20N6O
CAS Number:
Molecular Weight:
348.40
UNSPSC Code:
12352200
NACRES:
NA.77
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Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear (warmed)
storage temp.
room temp
Biochem/physiol Actions
Blood-brain barrier permeable HuR cytoplasmic dimerization inhibitor that reduces the stability of targeted mRNAs
SRI-42127 is a blood-brain barrier permeable imidazopyridazinamine analog that potently and reversibly inhibits the RNA-binding protein HuR multimerization and blocks HuR nucleocytoplasmic shuttling. SRI-42127 suppresses the expression and release of several pro-inflammatory mediators with minimal effect on anti-inflammatory cytokines. SRI 42127 weakens HuR interaction with Bcl-2 and Mcl-1 leading to induction of apoptosis and decreased tumor growth. SRI42127 subdues microglial activation in vivo and attenuates the recruitment/chemotaxis of neutrophils and monocytes.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Inhibition of the RNA Regulator HuR by SRI-42127 Attenuates Neuropathic Pain After Nerve Injury Through Suppression of Neuroinflammatory Responses
Neurotherapeutics, 19(5), 1649-1661 (2022)
Targeting the HuR Oncogenic Role with a New Class of Cytoplasmic Dimerization Inhibitors
Cancer research, 81(8), 2220-2233 (2021)
SRI-42127, a novel small molecule inhibitor of the RNA regulator HuR, potently attenuates glial activation in a model of lipopolysaccharide-induced neuroinflammation
Glia, 70(1), 155-172 (2022)
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