This product is intended for research use only. It is not suitable for any other purpose, which includes, but is not limited to, unauthorized commercial use, in vitro diagnostic use, or therapeutic use in humans or animals.
SML3002
Sulfuretin
≥98% (HPLC)
Synonym(s):
Sulfuretin, Sulphuretin
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5 MG
RM 809.00
About This Item
Empirical Formula (Hill Notation):
C15H10O5
Molecular Weight:
270.24
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
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description
≥98% (HPLC)
Quality Level
Assay
≥98% (HPLC)
form
solid
storage temp.
2-8°C
SMILES string
OC1=CC=C2C(O/C(C2=O)=C\C3=CC(O)=C(O)C=C3)=C1
InChI
1S/C15H10O5/c16-9-2-3-10-13(7-9)20-14(15(10)19)6-8-1-4-11(17)12(18)5-8/h1-7,16-18H/b14-6-
InChI key
RGNXWPVNPFAADO-NSIKDUERSA-N
General description
Sulfuretin is an aurones flavonoid found in the extract of Rhus verniciflua. The Extract of Rhus verniciflua is known in the traditional medicine and scientific community to have anti-cancer properties.Sulfuretin, one of the major constituents of Rhus verniciflua extract was found to have anti-cancer activities via activation of caspase-3 and inhibition of PARP. Moreover, sulfuretin downregulates cyclin D proteins by increasing the expression of miR-30C, a tumor suppressor micro RNA that is studied in regulation of cell proliferation.2 Structure-activity relationships (SAR) of Sulfuretin analogs inhibits the proliferation of leukemia cancer line panel in vitro and in vivo in zebrafish and mice models.Furthermore, Sulfuretin 100mg/Kg in vivo study was beneficial in treating lymphoedema in mice.In addition, Sulfuretin has several other activities such as:
- Sulfuretin is an anti-adipogenic agent, suppressing the adipogenic factors C/EBPα, C/EBPβ and PPARγ, which are crucial regulators at the initial step of adipogenesis.
- Sulfuretin is a potent antioxidant which protects SH-SY5Y cell line from 6-OHDA induced ROS.
- Sulfuretin has antiviral activity through the inhibition of influenza virus neuraminidase in IC50 of 36μM.
Biochem/physiol Actions
Anti-adipogenic, antineoplastic activity, antioxidative stress, Anti-Inflammatory
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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