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SML2940

Sigma-Aldrich

ML417

≥98% (HPLC)

Synonym(s):

(1H-Indol-2-yl)(4-(2-(4-methoxyphenoxy)ethyl)piperazin-1-yl)methanone, Methanone, 1H-indol-2-yl[4-[2-(4-methoxyphenoxy)ethyl]-1-piperazinyl]-

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5 MG
RM 464.00
25 MG
RM 1,871.00

RM 464.00

Estimated to ship on28 March 2025

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5 MG
RM 464.00
25 MG
RM 1,871.00

About This Item

Empirical Formula (Hill Notation):
C22H25N3O3
CAS Number:
1386162-69-1
Molecular Weight:
379.45
MDL number:
MFCD32693923
UNSPSC Code:
12352200
NACRES:
NA.77

RM 464.00

Estimated to ship on28 March 2025

Request a Bulk Order

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

N2(CCN(CC2)C(=O)c3[nH]c4c(c3)cccc4)CCOc1ccc(cc1)OC

Biochem/physiol Actions

ML417 is a blood-brain barrier permeable, potent and highly selective agonist of D3 dopamine receptor (D3R) with very limited cross-reactivity at other GPCRs. ML417 potently induces G-protein activation, D3R-mediated b-arrestin translocation and pERK phosphorylation. It does not activate other dopamine receptors. ML417 protect D3R-expressing dopaminergic neurons from 6-OHDA induced cell death.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Amy E Moritz et al.
Journal of medicinal chemistry, 63(10), 5526-5567 (2020-04-29)
To identify novel D3 dopamine receptor (D3R) agonists, we conducted a high-throughput screen using a β-arrestin recruitment assay. Counterscreening of the hit compounds provided an assessment of their selectivity, efficacy, and potency. The most promising scaffold was optimized through medicinal

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