SML2609
JH-I-25
≥98% (HPLC)
Synonym(s):
N-[2-Methoxy-4-(4-morpholinyl)phenyl]-6-(1H-pyrazol-3-yl)-2-pyridinecarboxamide
Sign Into View Organizational & Contract Pricing
All Photos(1)
About This Item
Empirical Formula (Hill Notation):
C20H21N5O3
CAS Number:
Molecular Weight:
379.41
UNSPSC Code:
12352200
NACRES:
NA.77
Recommended Products
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear (warmed)
storage temp.
2-8°C
SMILES string
O=C(NC1=C(C=C(C=C1)N2CCOCC2)OC)C3=NC(C4=NNC=C4)=CC=C3
Biochem/physiol Actions
JH-I-25 is a potent and selective type I inhibitor of IRAK1 and IRAK4 (interleukin-1 receptor–associated kinase 1 and 4). JH-I-25 binds preferentially to the unphosphorylated the ATP-site of the kinase in its active, DFG-in, state.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Li Wang et al.
The Journal of biological chemistry, 294(12), 4511-4519 (2019-01-27)
Interleukin-1 receptor-associated kinase 4 (IRAK4) is a key player in innate immune and inflammatory responses, performing a critical role in signal transduction downstream of Toll-like receptors and interleukin-1 (IL-1) receptors. Upon ligand binding and via its N-terminal death domain, IRAK4
Li Wang et al.
Proceedings of the National Academy of Sciences of the United States of America, 114(51), 13507-13512 (2017-12-07)
Interleukin 1 (IL-1) receptor-associated kinases (IRAKs) are serine/threonine kinases that play critical roles in initiating innate immune responses against foreign pathogens and other types of dangers through their role in Toll-like receptor (TLR) and interleukin 1 receptor (IL-1R) mediated signaling
George M Buckley et al.
Bioorganic & medicinal chemistry letters, 18(11), 3211-3214 (2008-05-14)
The synthesis and profile of a series of amides are described. Some of these compounds were potent IRAK-4 inhibitors and two examples were evaluated in vivo.
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service