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SML2539

Sigma-Aldrich

NAB-14

≥98% (HPLC)

Synonym(s):

Carbamic acid, N,N-diethyl-, 4-[(1H-indol-7-ylamino)carbonyl]phenyl ester

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5 MG
RM 435.00
25 MG
RM 1,754.00

RM 435.00

Estimated to ship on21 March 2025

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5 MG
RM 435.00
25 MG
RM 1,754.00

About This Item

Empirical Formula (Hill Notation):
C20H21N3O3
CAS Number:
1237541-73-9
Molecular Weight:
351.40
UNSPSC Code:
12352200
NACRES:
NA.77

RM 435.00

Estimated to ship on21 March 2025

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Assay

≥98% (HPLC)

form

powder

color

white to gray

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

CCN(CC)C(OC(C=C1)=CC=C1C(NC2=C3C(C=CN3)=CC=C2)=O)=O

InChI

1S/C20H21N3O3/c1-3-23(4-2)20(25)26-16-10-8-15(9-11-16)19(24)22-17-7-5-6-14-12-13-21-18(14)17/h5-13,21H,3-4H2,1-2H3,(H,22,24)

InChI key

WCGIKJOMEYPSIP-UHFFFAOYSA-N

Biochem/physiol Actions

NAB-14 is a negative allosteric modulator (NAM) selective for GluN2C/2D-containing NMDA glutamate receptors. NAB-14 was >800-fold selective for recombinant GluN2C/GluN2D over GluN2A/GluN2B in Xenopus oocytes and exhibited an IC50 value of 580 nM at recombinant GluN1/GluN2D receptors.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000348796
0000348796
0000209599
0000209600
0000209600

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Sharon A Swanger et al.
ACS chemical neuroscience, 9(2), 306-319 (2017-10-19)
N-Methyl-d-aspartate receptors (NMDARs) are ionotropic glutamate receptors that mediate excitatory synaptic transmission and have been implicated in numerous neurological disorders. NMDARs typically comprise two GluN1 and two GluN2 subunits. The four GluN2 subtypes (GluN2A-GluN2D) have distinct functional properties and gene
Lulu Yao et al.
Nature communications, 9(1), 4000-4000 (2018-10-03)
Selective disruption of synaptic drive to inhibitory neurons could contribute to the pathophysiology of various brain disorders. We have previously identified a GluN2A-selective positive allosteric modulator, GNE-8324, that selectively enhances N-methyl-D-aspartate receptor (NMDAR)-mediated synaptic responses in inhibitory but not excitatory

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