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Key Documents

SMB00608

Sigma-Aldrich

Potassium clavulanate: silicon dioxide (1:1)

Synonym(s):

Potassium clavulanate: silicon dioxide

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About This Item

UNSPSC Code:
12352200

form

powder

color

off-white

solubility

water: 1 mg/mL, clear to slightly hazy

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria

Mode of action

enzyme | inhibits

storage temp.

2-8°C

General description

Material is a powdered mixture of 1 part potassium clavulanate to 1 part silicon dioxide.

Biochem/physiol Actions

Clavulanate is a β-lactam antibiotic related to the penicillins. Clavulanate competitively and irreversibly inhibits a wide variety of β-lactamases found in bacteria that are resistant to penicillins and cephalosporins.

Packaging

1G

Storage and Stability

Keep container tightly closed in a dry and well-ventilated place. Never allow produc to get in contact with water during storage.

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Never allow product to get in contact with water during storage.

Pictograms

FlameHealth hazard
GHS02,GHS08

Signal Word

Danger

Hazard Statements

H252,H317,H334,H372

Hazard Classifications

Resp. Sens. 1 - Self-heat. 2 - Skin Sens. 1 - STOT RE 1 Inhalation

Target Organs

Lungs

Supplementary Hazards

EUH014,EUH044

Storage Class Code

4.2 - Pyrophoric and self-heating hazardous materials

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
096M4874V

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B G Spratt et al.
Antimicrobial agents and chemotherapy, 12(3), 406-409 (1977-09-01)
Thienamycin and clavulanic acid are new beta-lactam derivatives with structures markedly different from those of penicillins or cephalosporins. Both derivatives had the same general mode of action as typical beta-lactam antibiotics since they bound to precisely the same proteins as
C Reading et al.
Antimicrobial agents and chemotherapy, 11(5), 852-857 (1977-05-01)
A novel beta-lactamase inhibitor has been isolated from Streptomyces clavuligerus ATCC 27064 and given the name clavulanic acid. Conditions for the cultivation of the organism and detection and isolation of clavulanic acid are described. This compound resembles the nucleus of

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