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SMB00295

Sigma-Aldrich

Ruscogenin

≥98% (HPLC)

Synonym(s):

(1β,3β,25R)-Spirost-5-ene-1,3-diol

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About This Item

Empirical Formula (Hill Notation):
C27H42O4
CAS Number:
472-11-7
Molecular Weight:
430.62
MDL number:
MFCD00210550
UNSPSC Code:
12352205
PubChem Substance ID:
329824928
NACRES:
NA.25

Assay

≥98% (HPLC)

form

powder

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

storage temp.

−20°C

SMILES string

C[C@H](CC1)CO[C@]21O[C@@]3([H])C[C@@]4([H])[C@]5([H])CC=C6C[C@@H](O)C[C@@H](O)[C@]6(C)[C@@]5([H])CC[C@]4(C)[C@@]3([H])[C@@H]2C

InChI

1S/C27H42O4/c1-15-7-10-27(30-14-15)16(2)24-22(31-27)13-21-19-6-5-17-11-18(28)12-23(29)26(17,4)20(19)8-9-25(21,24)3/h5,15-16,18-24,28-29H,6-14H2,1-4H3/t15-,16+,18-,19-,20+,21+,22+,23-,24+,25+,26+,27-/m1/s1

InChI key

QMQIQBOGXYYATH-IDABPMKMSA-N

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General description

Ruscogenin is a major steroidal saponin found in the root of Ophiopogon japonicus. It was first isolated from Ruscus aculeatus.

Application

Ruscogenin has been used to study its therapeutic effects on Crohn′s disease (CD)-like colitis both in vitro and in vivo studies.

Biochem/physiol Actions

Ruscogenin is a well-known compound for down-regulating nuclear factor kappa B (NF-κB), intercellular adhesion molecule-1 (ICAM-1), tissue factor (TF), inducible NO synthase (iNOS), and modulating inflammatory pathways. It displays anti-inflammatory properties by inhibiting lipopolysaccharide (LPS)-induced acute lung injury (ALI), and improving diabetic nephropathy in in vivo studies. Ruscogenin also exerts neuroprotective properties and protects the brain against ischemic injury in mouse model. It elicits anti-tumor properties by inducing ferroptosis in pancreatic cancer cells in both in vitro and in vivo studies.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Zhiwang Song et al.
Oncology reports, 43(2), 516-524 (2020-01-03)
Pancreatic cancer is characterized by aggressive and highly metastatic phenotypes. This disease exhibits a poor patient prognosis and is considered a challenge due to the limited treatment options encountered in clinical practice. Previous studies have shown that ruscogenin, a saponin
Low-frequency components of cardiovascular variabilities as markers of sympathetic modulation.
M Pagani et al.
Trends in pharmacological sciences, 13(2), 50-54 (1992-02-01)
C J O'Brien et al.
World journal of surgery, 16(2), 222-226 (1992-03-01)
This retrospective study examines the experience of the Sydney Melanoma Unit in the management of cervical lymph nodes among patients with cutaneous melanoma of the head and neck. From 1960 to 1990, 397 patients had neck dissections for cutaneous malignant
Qi Sun et al.
International immunopharmacology, 12(1), 88-93 (2011-11-15)
Acute lung injury is still a significant clinical problem with a high mortality rate and there are few effective therapies in clinic. Here, we studied the inhibitory effect of ruscogenin, an anti-inflammatory and anti-thrombotic natural product, on lipopolysaccharide (LPS)-induced acute
Domains of muscarinic acetylcholine receptors that confer specificity of G protein coupling.
T I Bonner
Trends in pharmacological sciences, 13(2), 48-50 (1992-02-01)
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