Anti-CHP2 antibody detects endogenous levels of total CHP2 protein.
The CHP2 (calcineurin like EF-hand protein 2) gene is mapped to human chromosome 16p12.2. It encodes a 23kDa protein containing myristoylation site at its N-terminal and four EF-hand Ca2+ binding motifs. The gene is predominantly expressed in small intestine and cancer cells.
Immunogen
The antiserum was produced against synthesized peptide derived from human CHP2.
Immunogen Range: 101-150
Biochem/physiol Actions
The protein encoded by CHP2 (calcineurin like EF-hand protein 2) gene serves as an important cofactor of Na+/H+ exchanger isoform 1 and maintains high intracellular pH in cancer cells. CHP2 protects cells from dying due to serum deprivation. Overexpression of the gene is observed in ovarian cancer and it is involved in the growth, proliferation, invasion and metastasis of cancer cells.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Crystal structure of CHP2 complexed with NHE1-cytosolic region and an implication for pH regulation.
Ammar YB
The Embo Journal, 25(11), 2315-2325 (2006)
Overexpression of CHP2 enhances tumor cell growth, invasion and metastasis in ovarian cancer.
Jin Q
In Vivo, 21(4), 593-598 (2007)
Crystallization and preliminary crystallographic analysis of the human calcineurin homologous protein CHP2 bound to the cytoplasmic region of the Na+/H+ exchanger NHE1.
Nuclear accumulation of calcineurin B homologous protein 2 (CHP2) results in enhanced proliferation of tumor cells.
Li QH
Genes Cells, 16(4), 416-426 (2011)
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