NKTR (Natural killer-tumor recognition sequence) is a 150kDa subunit of a putative tumor-recognition complex. It is expressed on the surface of natural killer cells. It contains an amino-terminal hydrophobic region, a cyclophilin-related domain, three histone-like domains, and three arginine and serine-rich domains.
Immunogen
The antiserum was produced against synthesized peptide derived from human NKTR.
Immunogen Range: 784-833
Application
Anti-NKTR antibody produced in rabbit is suitable for immunohistochemistry and indirect immunofluorescence studies.
Biochem/physiol Actions
NKTR (Natural killer-tumor recognition sequence) plays an important role in NK-cell cytotoxicity in human T-cells. It participates in identifying as well as NK-like killing. It has been reported that IL2 (interleukin 2) control the NKTR activity by altering the RNA splicing pattern.
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Proceedings of the National Academy of Sciences of the United States of America, 90(2), 542-546 (1993-01-15)
Natural killer cells are non-major histocompatibility complex-restricted large granular lymphocytes that can recognize and destroy tumor cells without prior stimulation. A 150-kDa molecule on the surface of human natural killer cells was identified as a component of a putative tumor-recognition
Journal of immunology (Baltimore, Md. : 1950), 152(6), 2669-2674 (1994-03-15)
NK cells lyse target cells without previous immune sensitization. A small subset of T cells also exhibits NK-like activity, which is distinct from TCR-mediated, MHC-restricted, and MHC-unrestricted cytotoxicity. We recently cloned a gene, NK-TR, which is postulated to be part
We have recently isolated and characterized human and mouse genes of a putative natural killer (NK) cell tumour-recognition protein (NK-TR) that is specifically expressed in NK cells. This gene codes for a 150 kD protein with a cyclophilin-related amino terminus
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