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SAB1401365

Anti-SLC14A1 antibody produced in rabbit

Name: Anti-SLC14A1 antibody produced in rabbit
Brand: SIGMA

purified immunoglobulin, buffered aqueous solution

Synonym(s):

FLJ33745, FLJ41687, HUT11, HsT1341, JK, RACH1

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

mouse, human

technique(s)

western blot: 1 μg/mL

NCBI accession no.

BC050539

UniProt accession no.

Q13336

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... SLC14A1(6563)

General description

The protein encoded by this gene is a membrane transporter that mediates urea transport in erythrocytes. This gene forms the basis for the Kidd blood group system. (provided by RefSeq)

Immunogen

SLC14A1 (AAH50539.1, 1 a.a. ~ 389 a.a) full-length human protein.

Sequence
MEDSPTMVRVDSPTMVRGENQVSPCQGRRCFPKALGYVTGDMKELANQLKDKPVVLQFIDWILRGISQVVFVNNPVSGILILVGLLVQNPWWALTGWLGTVVSTLMALLLSQDRSLIASGLYGYNATLVGVLMAVFSDKGDYFWWLLLPVCAMSMTCPIFSSALNSVLSKWDLPVFTLPFNMALSMYLSATGHYNPFFPAKLVIPITTAPNISWSDLSALELLKSIPVGVGQIYGCDNPWTGGIFLGAILLSSPLMCLHAAIGSLLGIAAGLSLSAPFENIYFGLWGFNSSLACIAMGGMFMALTWQTHLLALGCALFTAYLGVGMANFMAEVGLPACTWPFCLATLLFLIMTTKNSNIYKMPLSKVTYPEENRIFYLQAKKRMVESPL

Biochem/physiol Actions

SLC14A1 (solute carrier family 14 member 1) mediates the transport of urea across cell membrane and maintains its concentration in bladder urothelial cells. Variation or mutation in SLC14A1 is associated with the risk of bladder cancer and also with hypertension and metabolic syndrome. Thus, the gene serves as an important prognostic marker in the detection of urothelial carcinoma. SLC14A1 knockout promotes DNA damage and cell death in bladder urothelium. In human, silencing SLC14A1 gene accounts for Kidd blood type and therefore, the gene plays a role in transfusion medicine and organ transplantation.

Physical form

Solution in phosphate buffered saline, pH 7.4

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Clinical aspects of urea transporters.

Jianhua Ran et al.

Sub-cellular biochemistry, 73, 179-191 (2014-10-10)

Jk antigens, which were identified as urea transporter B (UT-B) in the plasma membrane of erythrocytes, and which determine the Kidd blood type in humans, are involved in transfusion medicine, and even in organ transplantation. The Jk(a-b-) blood type is

New advances in urea transporter UT-A1 membrane trafficking.

Chen G

International Journal of Molecular Sciences, 14(5), 10674-10682 (2013)

Clinical significance of the reduction of UT-B expression in urothelial carcinoma of the bladder.

Li C

Pathology Research and Practice, 210(12), 799-803 (2014)

Replicative study of GWAS TP63C/T, TERTC/T, and SLC14A1C/T with susceptibility to bladder cancer in North Indians.

Singh V

Urologic Oncology, 32(8), 1209-1214 (2014)