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S0577

Sigma-Aldrich

Streptokinase C from Streptococcus sp.

lyophilized solid, ≥3,500 unit/mg solid

Synonym(s):

Streptokinase

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About This Item

Enzyme Commission number:
3.4.99.0 (BRENDA, IUBMB)
UNSPSC Code:
12352204
NACRES:
NA.54

biological source

bacterial (Streptococcus sp.)

Quality Level

200

recombinant

expressed in E. coli

Assay

40—60% protein (biuret)

form

lyophilized solid

specific activity

≥3,500 unit/mg solid

color

off-white to light yellow

application(s)

life science and biopharma

storage temp.

−20°C

Gene Information

Streptococcus pyogenes ... SKC(134997)

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General description

Research area: Cell Signaling

Streptokinase is an extracellular enzyme, a single-chain polypeptide produced by several strains of β-hemolytic Streptococci. It is composed of multiple structural domains like α-, β-, and γ-domains that are involved in various functions.

Application

Streptokinase C from Streptococcus sp. has been used to quantitate the survival of Staphylococcus aureus in whole human blood.

Biochem/physiol Actions

Streptokinase shows fibrinolytic activity by triggering the circulatory plasminogen either via a fibrin-dependent or fibrin-independent mechanism. Streptokinase has been studied majorly in terms of its therapeutic efficacy and treating myocardial infarction to dissolve clots.

Unit Definition

One unit will liquify a standard clot of fibrinogen, plasminogen, and thrombin at pH 7.5 at 37 °C in 10 min.

Physical form

Lyophilized powder containing approx. 50% bovine serum albumin (total protein by biuret) with sodium glutamate.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Kerstin Steiner et al.
Infection and immunity, 70(7), 3627-3636 (2002-06-18)
Synthesis of the plasminogen activator streptokinase (SK) by group A streptococci (GAS) has recently been shown to be subject to control by two two-component regulators, covRS (or csrRS) and fasBCA. In independent studies, response regulator CovR proved to act as
Streptokinase production from Streptococcus dysgalactiae subsp. equisimilis SK-6 in the presence of surfactants, growth factors and trace elements
Bhardwaj S and Angayarkann J
3 Biotech, 5(2), 187?193-187?193 (2015)
Jakub M Kwiecinski et al.
Cell reports, 36(4), 109462-109462 (2021-07-29)
Skin is one of the most common sites of host immune response against Staphylococcus aureus infection. Here, through a combination of in vitro assays, mouse models, and intravital imaging, we find that S. aureus immune evasion in skin is controlled by a

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