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RAB0078

Sigma-Aldrich

Human MCP-3 / CCL7 ELISA Kit

for serum, plasma, cell culture supernatant and urine

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About This Item

UNSPSC Code:
41116158
NACRES:
NA.32

species reactivity

human

packaging

kit of 96 wells (12 strips x 8 wells)

technique(s)

ELISA: suitable
capture ELISA: suitable

input

sample type serum
sample type cell culture supernatant(s)
sample type urine
sample type plasma

assay range

inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 20 pg/mL
standard curve range: 24.58-6000 pg/mL

detection method

colorimetric

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... CCL7(6354)

General description

The Human MCP-3 (Monocyte Chemoattractant Protein-3) ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme- linked immunosorbent assay for the quantitative measurement of human MCP-3 in serum, plasma, cell culture supernatants and urine.

Immunogen

Recombinant Human MCP3

Application

For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)

Biochem/physiol Actions

Monocyte-chemotactic protein 3 (MCP3), also known as chemokine (C-C motif) ligand 7 (CCL7), has an ability to attract and activate a large panel of leukocytes including monocytes, eosinophils, basophils, dendritic cells, natural killer cells and activated T lymphocytes. This property of the protein makes it favorable for antitumor therapy. Mutation in the gene is associated with the development of Crohn′s Disease (CD). Elevated expression of the gene contributes to the development of gastric cancer (GC). Thus, it acts as a potent diagnostic marker for GC.

Other Notes

A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.

Kit Components Also Available Separately

Product No.
Description
SDS
  • RABELADBELISA 5X Assay/Sample Diluent Buffer B (Item E1)SDS
  • RABELADCELISA 1X Assay/Sample Diluent Buffer C (Item L)SDS
  • RABSTOP3ELISA Stop Solution (Item I)SDS
  • RABTMB3ELISA Colorimetric TMB Reagent (HRP Substrate, Item H)SDS
  • RABWASH420X Wash Buffer (Item B)SDS

Pictograms

Corrosion
GHS05

Signal Word

Warning

Hazard Statements

H290

Precautionary Statements

P234 - P390

Hazard Classifications

Met. Corr. 1

Storage Class Code

8A - Combustible corrosive hazardous materials

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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CCL7 and CCL21 overexpression in gastric cancer is associated with lymph node metastasis and poor prognosis
Hwang TL, et al.
World Journal of Gastroenterology, 18(11), 1249-1249 (2012)
MCP?3 (CCL7) delivered by parvovirus MVMp reduces tumorigenicity of mouse melanoma cells through activation of T lymphocytes and NK cells
Wetzel K, et al.
International Journal of Cancer. Journal International Du Cancer, 120(6), 1364-1371 (2007)
The Genomics of Autoimmune Disease in the Era of Genome-Wide Association Studies and Beyond
Lessard CJ, et al.
Autoimmunity Reviews, 11(4), 267-275 (2012)

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