P2110
Anti-Platelet-Derived Growth Factor Receptor α antibody produced in goat
affinity isolated antibody, lyophilized powder
Synonym(s):
Anti-PDGF Rα
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About This Item
biological source
goat
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
species reactivity
human
technique(s)
direct ELISA: 0.5-1.0 μg/mL
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 15 μg/mL using human tissue sections
neutralization: suitable
western blot: 0.1-0.2 μg/mL
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... PDGFRA(5156)
General description
Blocks cell surface human or mouse PDGF Receptor α mediated biological activity induced by PDGF-AA.
Immunogen
recombinant soluble human platelet-derived growth factor receptor α expressed in Sf 21 cells.
Biochem/physiol Actions
Platelet-derived growth factor (PDGF) is a serum growth factor purified from human platelets. The cellular effects of PDGF are mediated by binding to PDGF α- and PDGF β-receptors which leads to activation of downstream signaling via PI3K, STAT and Ras/MAPK. PDGFR stimulates the proliferation of cells of connective tissue and glial cells, survival, differentiation, chemotaxis and wound healing.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
13 - Non Combustible Solids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Noortje A M Bax et al.
Developmental dynamics : an official publication of the American Association of Anatomists, 238(10), 2658-2669 (2009-08-26)
For the establishment of a fully functional septated heart, addition of myocardium from second heart field-derived structures is important. Platelet-derived growth factors (PDGFs) are known for their role in cardiovascular development. In this study, we aim to elucidate this role
Nynke M S Van Den Akker et al.
Developmental dynamics : an official publication of the American Association of Anatomists, 233(4), 1579-1588 (2005-06-24)
Platelet-derived growth factors (PDGFs) are important in embryonic development. To elucidate their role in avian heart and coronary development, we investigated protein expression patterns of PDGF-A, PDGF-B, and the receptors PDGFR-alpha and PDGFR-beta using immunohistochemistry on sections of pro-epicardial quail-chicken
Daniel F Bowen-Pope et al.
Arteriosclerosis, thrombosis, and vascular biology, 31(11), 2397-2401 (2011-10-21)
A growth-promoting activity released from activated platelets, the platelet-derived growth factor, was discovered and characterized while the cellular and molecular mechanisms underlying the formation of the lesions of atherosclerosis were being investigated. This review provides a personal account of the
Carl-Henrik Heldin
Upsala journal of medical sciences, 117(2), 83-91 (2012-04-20)
Platelet-derived growth factor (PDGF) isoforms are important mitogens for different types of mesenchymal cells, which have important functions during the embryonal development and in the adult during wound healing and tissue homeostasis. In tumors, PDGF isoforms are often over-expressed and
Johanna Andrae et al.
Genes & development, 22(10), 1276-1312 (2008-05-17)
Platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) have served as prototypes for growth factor and receptor tyrosine kinase function for more than 25 years. Studies of PDGFs and PDGFRs in animal development have revealed roles for PDGFR-alpha signaling in
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