P1382

Phenoxymethylpenicillinic acid potassium salt

potency: 1444-1536 units per mg

• Synonym(s): Penicillin V potassium salt
• Empirical Formula (Hill Notation): C₁₆H₁₇N₂O₅SK
• Molecular Weight: 388.48
• EC Number: 205-086-5
• MDL number: MFCD00051771
• UNSPSC Code: 12352106
• PubChem Substance ID: 24898194
• NACRES: NA.85

Properties

• form: solid
• potency: 1444-1536 units per mg
• antibiotic activity spectrum: Gram-positive bacteria
• Mode of action: cell wall synthesis | interferes
• SMILES string: [K+].CC1(C)S[C@@H]2[C@H](NC(=O)COc3ccccc3)C(=O)N2[C@H]1C([O-])=O
• InChI: 1S/C16H18N2O5S.K/c1-16(2)12(15(21)22)18-13(20)11(14(18)24-16)17-10(19)8-23-9-6-4-3-5-7-9;/h3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22);/q;+1/p-1/t11-,12+,14-;/m1./s1
• InChI key: HCTVWSOKIJULET-LQDWTQKMSA-M

Description

General description

Chemical structure: ß-lactam

Application

Phenoxymethylpenicillinic acid, also known as Penicillin V, is a narrow spectrum antibiotic used to treat mild to moderate infections caused by susceptible bacteria. It is a natural penicillin antibiotic that is administered orally. Penicillin V is a penicillin β-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. It is commonly used in cell culture in combination with streptomcyin and other antibiotics. It is used to study penicillin-binding protein 2, molecular cloning of the Bacillus sphaericus penicillin V amidase gene, and gastrointestinal persistence and bile tolerance of Listeria monocytogenes.

Biochem/physiol Actions

Phenoxymethylpenicillinic acid binds to specific penicillin-binding proteins (PBPs) and inhibits the synthesis of bacterial cell walls by preventing cell wall peptidoglycan chain cross-linking. This causes cell lysis, which is mediated by autolytic enzymes such as autolysins. Phenoxymethylpenicillnic acid may interfere with autolysin inhibitors.

Other Notes

10mu,100mu

Keep container tightly closed in a dry and well-ventilated place.

Safety Information

• Pictograms: GHS08,GHS07
• Signal Word: Danger
• Hazard Statements: H302,H317,H334
• Precautionary Statements: P280 - P301 + P312 + P330 - P302 + P352
• Hazard Classifications: Acute Tox. 4 Oral - Resp. Sens. 1 - Skin Sens. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable