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P126

Sigma-Aldrich

Pirenperone

>97%, solid

Synonym(s):

3-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-2-methyl-4H-pyrido-[1,2-a] pyrimidin-4-one, R-47,465

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About This Item

Empirical Formula (Hill Notation):
C23H24FN3O2
CAS Number:
75444-65-4
Molecular Weight:
393.45
EC Number:
278-213-5
MDL number:
MFCD00069332
UNSPSC Code:
12352200
PubChem Substance ID:
24278110

Quality Level

200

Assay

>97%

form

solid

color

light yellow

solubility

0.1 M HCl: 11 mg/mL
methanol: 2.5 mg/mL
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 5.0 mg/mL

SMILES string

CC1=C(CCN2CCC(CC2)C(=O)c3ccc(F)cc3)C(=O)N4C=CC=CC4=N1

InChI

1S/C23H24FN3O2/c1-16-20(23(29)27-12-3-2-4-21(27)25-16)11-15-26-13-9-18(10-14-26)22(28)17-5-7-19(24)8-6-17/h2-8,12,18H,9-11,13-15H2,1H3

InChI key

HXCNRYXBZNHDNE-UHFFFAOYSA-N

Gene Information

human ... HTR2A(3356) , HTR2B(3357) , HTR2C(3358)

Biochem/physiol Actions

5-HT2 serotonin receptor antagonist.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
048H4736

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J P Valentin et al.
Methods and findings in experimental and clinical pharmacology, 17(4), 267-271 (1995-05-01)
We investigated the usefulness of the pithed rat model to determine the relative potencies of 5-HT2A/2C receptor antagonists following acute intravenous and oral administration in inhibiting 5-HT-induced pressor responses. The 5-HT2A/2C receptor antagonists, pirenperone, ketanserin, and ritanserin, all dose-dependently inhibited
T Yamamoto et al.
Neuropharmacology, 27(2), 123-127 (1988-02-01)
The present study was designed to examine the possible involvement of both an anti-serotonin action and a catecholamine-stimulating action in the mechanism of the inhibition of the muricide in rats with lesions of the midbrain raphe. Serotonin antagonists, such as
S Ahlenius et al.
Psychopharmacology, 98(4), 440-444 (1989-01-01)
5-Hydroxy-L-tryptophan (5-HTP), 25 mg kg-1 IP, in combination with the peripheral 5-HTP decarboxylase inhibitor benserazide, 25 mg kg-1 IP, and the selective inhibitor of neuronal 5-hydroxytryptamine (5-HT) re-uptake, zimeldine, 10 mg kg-1 IP, suppressed lordosis in ovariectomized female rats, treated
L H Raible
Pharmacology, biochemistry, and behavior, 30(1), 37-43 (1988-05-01)
Alpha-melanocyte stimulating hormone (MSH) has been found to exert a short- and a long-term inhibitory action on lordosis. The present series of experiments examined the possibility that these effects are mediated by MSH-induced alterations in activity at serotonin type II
D Paul et al.
Psychopharmacology, 100(1), 98-101 (1990-01-01)
The selective serotonin type-2 (S2) receptor blocker pirenperone (0.24 mg/kg, SC) attenuates morphine-produced tail-flick antinociception in intact rats, but not in rats with transected spinal cords. These results suggest that S2 receptor blockade does not affect intraspinal opioid antinociception. Together
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