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P0048

Sigma-Aldrich

Pemoline

≥98% (HPLC)

Synonym(s):

2-Amino-5-phenyl4(5H)-oxazolone, Phenylisohydantoin

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About This Item

Empirical Formula (Hill Notation):
C9H8N2O2
CAS Number:
2152-34-3
Molecular Weight:
176.17
EC Number:
218-438-8
MDL number:
MFCD00083197
UNSPSC Code:
12352200
PubChem Substance ID:
329819998
NACRES:
NA.77

Assay

≥98% (HPLC)

form

solid

drug control

USDEA Schedule IV; Home Office Schedule 4.2; psychotrope (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)

solubility

DMSO: 28 mg/mL

originator

Boehringer Ingelheim

storage temp.

2-8°C

SMILES string

NC1=NC(=O)C(O1)c2ccccc2

InChI

1S/C9H8N2O2/c10-9-11-8(12)7(13-9)6-4-2-1-3-5-6/h1-5,7H,(H2,10,11,12)

InChI key

NRNCYVBFPDDJNE-UHFFFAOYSA-N

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Biochem/physiol Actions

Pemoline is a CNS stimulant. Pemoline is used to treat attention-deficit hyperactivity disorder (ADHD). Pemoline is a Schedule IV drug and offers some advantages over other stimulants in that it does not reduce the appetite or cause dry mouth.

Features and Benefits

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Boehringer Ingelheim. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302 + H312 + H332

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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A M Muehlmann et al.
Journal of intellectual disability research : JIDR, 56(5), 490-500 (2011-10-13)
Self-injurious behaviour (SIB) is prevalent in neurodevelopmental disorders, but its expression is highly variable within, and between diagnostic categories. This raises questions about the factors that contribute to aetiology and expression of SIB. Expression of SIB is generally described in
Vera Peuckmann et al.
The Cochrane database of systematic reviews, (11)(11), CD006788-CD006788 (2010-11-12)
In healthy individuals, fatigue is a protective response to physical or mental stress, often relieved by rest. By contrast, in palliative care patients fatigue can be severely debilitating, thereby impacting daily activity and quality of life, often with rest not
Philip Shaw et al.
The American journal of psychiatry, 166(1), 58-63 (2008-09-17)
While there has been considerable concern over possible adverse effects of psychostimulants on brain development, this issue has not been examined in a prospective study. The authors sought to determine prospectively whether psychostimulant treatment for attention deficit hyperactivity disorder (ADHD)
Mark Olfson et al.
The Journal of clinical psychiatry, 74(1), 43-50 (2013-02-20)
The authors investigated trends and patterns in stimulant treatment of adults visiting office-based medical practices in the United States. A time series analysis of data from the 1994 to 2009 National Ambulatory Medical Care Surveys (no. of visits = 372,702)
Darragh P Devine
Methods in molecular biology (Clifton, N.J.), 829, 65-84 (2012-01-11)
Self-injurious behaviour is highly prevalent in neurodevelopmental disorders. Interestingly, it is not restricted to any individual diagnostic group. Rather, it is exhibited in various forms across patient groups with distinct genetic defects and classifications of disorders. This suggests that there
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