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I8283

Sigma-Aldrich

ICI 63,197

≥98% (HPLC)

Synonym(s):

2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-one

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About This Item

Empirical Formula (Hill Notation):
C9H13N5O
CAS Number:
27277-00-5
Molecular Weight:
207.23
EC Number:
248-383-5
MDL number:
MFCD06407961
UNSPSC Code:
41106305
PubChem Substance ID:
24896137
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

color

white

mp

161.8-163 °C

solubility

DMSO: 13 mg/mL

storage temp.

2-8°C

SMILES string

CCCN1C(=O)C(C)=Cn2nc(N)nc12

InChI

1S/C9H13N5O/c1-3-4-13-7(15)6(2)5-14-9(13)11-8(10)12-14/h5H,3-4H2,1-2H3,(H2,10,12)

InChI key

UQDVRVNMIJAGRK-UHFFFAOYSA-N

Biochem/physiol Actions

Phosphodiesterase IV (PDE 4) inhibitor

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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S P Canfield et al.
International journal of tissue reactions, 5(3), 241-243 (1983-01-01)
The effect of 5 hydroxytryptamine (5-HT) on gastric acid secretion by the rat isolated stomach has been studied. 5-HT (10 microM) significantly inhibited secretory responses to pentagastrin, histamine and isoprenaline but not those due to bethanechol, dibutyryl cyclic AMP or
H O Collier et al.
Federation proceedings, 40(5), 1513-1518 (1981-04-01)
A quasi-morphine withdrawal syndrome (QMWS) is a pattern of behavior closely resembling the true withdrawal syndrome in the opiate-dependent animal, which can be elicited acutely by a nonopiate drug in an opiate-naive animal. The main criteria proposed for the QMWS
H Wachtel
Psychopharmacology, 77(4), 309-316 (1982-01-01)
The significance of a characteristic symptomatology (hypothermia, hypoactivity, forepaw shaking, grooming, head twitches) as a potential in vivo correlate of enhanced availability of brain adenosine cyclic 3',5'-monophosphate (cAMP) was examined in rats following systemic administration of various doses of dibutyryladenosine
J Abrahamsen et al.
Naunyn-Schmiedeberg's archives of pharmacology, 343(2), 161-165 (1991-02-01)
The aim of the present investigation was to examine whether or not presynaptic facilitatory beta-adrenoceptors are detectable on the postganglionic nerves in the rabbit isolated ear artery. Strips of rabbit central ear artery were incubated with 3H-noradrenaline (10(-7) mol/l; 30
M R Mustafa et al.
European journal of pharmacology, 148(2), 171-177 (1988-03-29)
The effects of single and chronic doses of rolipram on the sensitivity of alpha 2-adrenoceptors have been compared with the phosphodiesterase inhibitors, isobutylmethylxanthine (IBMX) and ICI 63,197, and the antidepressant, desipramine. While pretreatment with a single dose of rolipram, ICI
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