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I6005

Sigma-Aldrich

myo-Inositol hexasulfate hexapotassium salt

Synonym(s):

Inositol hexakissulfate, InsS6

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About This Item

Linear Formula:
C6H6O24S6K6
CAS Number:
28434-25-5
Molecular Weight:
889.08
MDL number:
MFCD00055894
UNSPSC Code:
12352201
PubChem Substance ID:
24896081

storage temp.

−20°C

SMILES string

[K].OS(=O)(=O)OC1C(OS(O)(=O)=O)C(OS(O)(=O)=O)C(OS(O)(=O)=O)C(OS(O)(=O)=O)C1OS(O)(=O)=O

InChI

1S/C6H12O24S6.K.H/c7-31(8,9)25-1-2(26-32(10,11)12)4(28-34(16,17)18)6(30-36(22,23)24)5(29-35(19,20)21)3(1)27-33(13,14)15;;/h1-6H,(H,7,8,9)(H,10,11,12)(H,13,14,15)(H,16,17,18)(H,19,20,21)(H,22,23,24);;

InChI key

JYVHCOUFXHFSLT-UHFFFAOYSA-N

Biochem/physiol Actions

InsS6 has a molecular footprint and negative surface charge that is similar to that of phytic acid (InsP6), but with lower biological activity. It is used as a control in studies of the cellular actions of phytic acid. It is also a competitive inhibitor of Aspergillus phytase.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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R Kojima et al.
Japanese journal of pharmacology, 53(3), 347-358 (1990-07-01)
We examined the protective effect of inositol hexasulfate (IS6) against tobramycin (TOB)-induced nephrotoxicity. In the electrophoretic analysis, TOB alone and IS6 alone were observed as single spots on the cathode and anode sides, respectively. However, in the mixture of TOB
G Oshima
Thrombosis research, 58(3), 243-250 (1990-05-01)
Thrombin-clotting time of fibrinogen was delayed by inositol hexasulfate (IHS). Clotting time of the recalcified plasma was also delayed by IHS. Moreover, when IHS was intravenously injected into anesthetized male rabbits (0.11 mmoles/kg), it delayed clotting time of the recalcified
N M Dean et al.
The Biochemical journal, 250(2), 493-500 (1988-03-01)
Previous studies demonstrated a multiplicity of isomers of inositol phosphates in GH3 rat pituitary tumour cells. In order to determine their origin, we have investigated the metabolism of radiolabelled inositol phosphates (IPn) in GH3 cell homogenates by using h.p.l.c. I(1,4,5)P3
Sonali P Jog et al.
Archives of biochemistry and biophysics, 440(2), 133-140 (2005-07-30)
Phytases catalyze the hydrolysis of phytic acid (InsP6, myo-inositol hexakisphosphate), the most abundant inositol phosphate in cells. In cereal grains and legumes, it constitutes 3-5% of the dry weight of seeds. The inability of humans and monogastric animals such as
M Guzmán-Casado et al.
International journal of biological macromolecules, 28(4), 305-313 (2001-04-20)
The interaction of an amino-terminal-truncated 139 amino-acids form of human acidic fibroblast growth factor with myo-inositol hexasulphate and low molecular weight (3500 g mol(-1)) heparin has been studied by isothermal titration calorimetry, differential scanning calorimetry and Fourier transform infrared spectroscopy.
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