Phosphodiesterase IV (PDE4) inhbitor. Inhibits platelet aggregation. Anti-asthma drug.
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Expert opinion on pharmacotherapy, 10(17), 2897-2904 (2009-11-26)
Ibudilast is a relatively nonselective phosphodiesterase inhibitor which has been marketed for almost 20 years in Japan for treating asthma. More recently it has been found to have anti-inflammatory activity in both the peripheral immune system and in the CNS
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 26(11), 4696-4709 (2012-08-15)
Chemotherapy-induced peripheral neuropathy (CIPN) is a debilitating side effect that occurs in many patients undergoing chemotherapy. It is often irreversible and frequently leads to early termination of treatment. In this study, we have identified two compounds, lithium and ibudilast, that
European journal of pharmacology, 637(1-3), 102-108 (2010-04-20)
Stress and renewed contact with drug (a "slip") have been linked to persisting relapse of methamphetamine abuse. Human brain microglial activation has been linked with methamphetamine abuse, and inhibitors of glial cell activation, certain phosphodiesterase (PDE) inhibitors, and glial cell
European journal of pharmacology, 701(1-3), 124-130 (2013-02-05)
Neuroinflammation induced by activated microglia and astrocytes can be elicited by drugs of abuse. Methamphetamine administration activates glial cells and increases proinflammatory cytokine production, and there is recent evidence of a linkage between glial cell activation and drug abuse-related behavior.
Human Immunodeficiency Virus-1 (HIV-1)-associated neurocognitive disorders (HAND) occur, in part, due to the inflammatory response to viral proteins, such as the HIV-1 transactivator of transcription (Tat), in the central nervous system (CNS). Given the need for novel adjunctive therapies for
Hello! I need to know whether I can prepare the working solution of the Ibudilast powder by diluting it in DMSO and freezing for storage at -20C. Will the compound be not degraded or damaged after freezing?
However, solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. The end-user will need to be cautious about keeping the product at -20°C for long-term storage and determine the stability at such temperatures empirically as this is not tested internally.
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