H9279
α-Hydroxyfarnesylphosphonic acid
2 mg/mL in ethanol
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About This Item
concentration
2 mg/mL in ethanol
storage temp.
−20°C
SMILES string
C\C(C)=C\CC\C(C)=C\CC\C(C)=C\C(O)P(O)(O)=O
Biochem/physiol Actions
Inhibitor of farnesyltransferase; much weaker activity against geranylgeranyl transferase.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Flam. Liq. 2
Storage Class Code
3 - Flammable liquids
WGK
WGK 2
Flash Point(F)
57.2 °F - closed cup - Solvent
Flash Point(C)
14.0 °C - closed cup - Solvent
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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The Journal of biological chemistry, 268(11), 7617-7620 (1993-04-15)
The ras oncogene product, Ras, is synthesized in vivo as a precursor protein that requires post-translational processing to become biologically active and to be capable of transforming mammalian cells. Farnesylation appears to be a critical modification of Ras, and thus
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