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About This Item
Empirical Formula (Hill Notation):
C43H65N7O9
CAS Number:
Molecular Weight:
824.02
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
Assay
≥97% (HPLC)
storage temp.
−20°C
SMILES string
CCCCC(NC=O)C(=O)NC(CC(C)C)C(=O)NC(Cc1ccccc1)C(=O)NC(CCCC)C(=O)NC(Cc2ccc(O)cc2)C(=O)NC(CCCCN)C(O)=O
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Biochem/physiol Actions
Potent chemoattractant for human neutrophils.
Radioiodinated molecule has full biological activity.
Radioiodinated molecule has full biological activity.
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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G Vaidyanathan et al.
Nuclear medicine and biology, 22(6), 759-764 (1995-08-01)
A potent chemotactic peptide, formyl-norleucyl-leucyl-phenylalanyl-norleucyl-tyrosyl-lysine was derivatized by reaction with N-succinimidyl 4-fluorobenzoate. This derivatized peptide bound to human polymorphonuclear leukocytes in vitro and exhibited biological activity in a superoxide production assay. Peptide labeling using N-succinimidyl 4-[18F]fluorobenzoate was accomplished in reasonable
H J Hertfelder et al.
European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies, 32(6), 441-447 (1994-06-01)
The release of polymorphonuclear leukocyte proteinases in buffy-coat-depleted red cell concentrates was examined during a storage period of 35 days. Collagenase, gelatinase and elastase predominantly induce breakdown of connective tissue. However, when released by cell disintegration during red cell concentrate
M I Ryder
Experimental lung research, 20(4), 283-296 (1994-07-01)
Alterations in neutrophil functions by tobacco components may play a pivotal role in pulmonary emphysema. This study examined the role of nicotine in altering F-actin formation and calcium (Ca2+) release (two early events in neutrophil motility). The effects of these
J Niedel
The Journal of biological chemistry, 256(17), 9295-9299 (1981-09-10)
The formyl peptide chemotactic receptor has been solubilized by digitonin treatment of purified human neutrophil membranes. Of several potential assay methods tested for their ability to separate receptor-bound from free ligand, only gel filtration through an acrylamide cross-linked agarose matrix
L A Sklar et al.
Proceedings of the National Academy of Sciences of the United States of America, 78(12), 7540-7544 (1981-12-01)
Antifluorescein antibody molecules were used to interrupt the stimulation of neutrophils by a fluoresceinated chemotactic peptide. From the results we construct a semiquantitative relationship among ligand-receptor interaction, the time course of cell triggering and response, and aspects of cellular adaptation.
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